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Correlation between drug dissolution and resistance to water-induced phase separation in solid dispersion formulations revealed by solid-state NMR spectroscopy.

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第一作者： Hitomi,Okada

第一单位： Graduate School of Pharmaceutical Sciences, Chiba University, 1-8-1 Inohana, Chuo-ku, Chiba 260-8675, Japan.

作者： Hitomi,Okada ^[1] ; Keisuke,Ueda ^[2] ; Yuki,Yasuda ^[1] ; Kenjirou,Higashi ^[1] ; Motoki,Inoue ^[3] ; Masataka,Ito ^[4] ; Shuji,Noguchi ^[4] ; Kohsaku,Kawakami ^[5] ; Kunikazu,Moribe ^[1]

作者单位： Graduate School of Pharmaceutical Sciences, Chiba University, 1-8-1 Inohana, Chuo-ku, Chiba 260-8675, Japan. ^[1] Graduate School of Pharmaceutical Sciences, Chiba University, 1-8-1 Inohana, Chuo-ku, Chiba 260-8675, Japan. Electronic address: keisuke@chiba-u.jp. ^[2] Department of Molecular Pharmaceutics, Meiji Pharmaceutical University, 2-522-1, Noshio, Kiyose, Tokyo 204-8588, Japan. ^[3] Faculty of Pharmaceutical Sciences, Toho University, 2-2-1 Miyama, Funabashi, Chiba 274-8510, Japan. ^[4] International Center for Materials Nanoarchitectonics, National Institute for Material Science, 1-1 Namiki, Tsukuba, Ibaraki 305-0044, Japan. ^[5]

关键词 Dissolution Drug-polymer interaction Miscibility Phase separation Solid dispersion