换一批
换一批Bioengineered miR-328-3p modulates GLUT1-mediated glucose uptake and metabolism to exert synergistic antiproliferative effects with chemotherapeutics.
第一作者：
Wanrong,Yi
第一单位：
Department of Orthopaedic Trauma and Microsurgery, Zhongnan Hospital of Wuhan University, Wuhan 430072, China.;Department of Biochemistry & Molecular Medicine, UC Davis School of Medicine, Sacramento 95817, CA, USA.
作者：
关键词
2-NBDG, 2-[N-(7-nitrobenz-2-oxa-1,3-diazol-4-yl) amino]-2-deoxyglucoseABCG2, ATP-binding cassette subfamily G member 2ACN, acetonitrileAu/Uv, absorbance unit of ultraviolet-visible spectroscopyBCRP, breast cancer resistant proteinBERA, bioengineered miRNA agentBioengineered RNACI, combination indexCPT, cisplatinCancerChemosensitivityDOX, doxorubicinE. coli, Escherichia coliESI, electrospray ionizationFPLC, fast protein liquid chromatographyFa, fraction affectedGLUT1GLUT1, glucose transporter protein type 1HCC, hepatocellular carcinomaHPLC, high-performance liquid chromatographyIS, internal standardKRB, Krebs–Ringer bicarbonateLAT1LAT1, large neutral amino acid transporter 1LC–MS/MS, liquid chromatography–tandem mass spectroscopyMCT4, monocarboxylate transporter 4MRE, miRNA response elementsMRM, multiple reaction monitoringMiR-328OS, osteosarcomaPAGE, polyacrylamide gel electrophoresisPTEN, phosphatase and tensin homologPVDF, Polyvinylidene fluorideRAGE, receptor for advanced glycosylation end productsRT-qPCR, reverse transcription quantitative real-time polymerase chain reactionSLC2A1, 7A5, 16A3, solute carrier family 2 member 1, family 7 member 5, family 16 member 3WT, wild typehBERA, humanized bioengineered miRNA agenthsa, Homo sapienshtRNASer, human seryl-tRNAmTOR, mammalian target of rapamycinmiR or miRNA, microRNAncRNA, noncoding RNAsnt, nucleotide
DOI
10.1016/j.apsb.2019.11.001
PMID
31993313
发布时间
2024-03-28
- 浏览3
Acta pharmaceutica Sinica. B
2020年10卷1期
159-170页
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