Structural Analysis of Rabies Virus Glycoprotein Reveals pH-Dependent Conformational Changes and Interactions with a Neutralizing Antibody.

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第一作者： Fanli,Yang

第一单位： West China Hospital Emergency Department (WCHED), State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University, Collaborative Innovation Center of Biotherapy, Chengdu, Sichuan 610041, China.

作者： Fanli,Yang ^[1] ; Sheng,Lin ^[1] ; Fei,Ye ^[1] ; Jing,Yang ^[1] ; Jianxun,Qi ^[2] ; Zhujun,Chen ^[1] ; Xi,Lin ^[1] ; Jichao,Wang ^[1] ; Dan,Yue ^[1] ; Yanwei,Cheng ^[1] ; Zimin,Chen ^[1] ; Hua,Chen ^[1] ; Yu,You ^[1] ; Zhonglin,Zhang ^[1] ; Yu,Yang ^[1] ; Ming,Yang ^[1] ; Honglu,Sun ^[1] ; Yuhua,Li ^[3] ; Yu,Cao ^[4] ; Shengyong,Yang ^[1] ; Yuquan,Wei ^[1] ; George F,Gao ^[5] ; Guangwen,Lu ^[6]

作者单位： West China Hospital Emergency Department (WCHED), State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University, Collaborative Innovation Center of Biotherapy, Chengdu, Sichuan 610041, China. ^[1] CAS Key Laboratory of Pathogenic Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences, Beijing 100101, China. ^[2] Division of Arboviral Vaccines, National Institutes of Food and Drug Control (NIFDC), Beijing 100050, China. ^[3] West China Hospital Emergency Department (WCHED), State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University, Collaborative Innovation Center of Biotherapy, Chengdu, Sichuan 610041, China; Disaster Medicine Center, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, China. ^[4] CAS Key Laboratory of Pathogenic Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences, Beijing 100101, China; Savaid Medical School, University of Chinese Academy of Sciences, Beijing 100049, China; National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention (China CDC), Beijing 102206, China; Research Network of Immunity and Health (RNIH), Beijing Institutes of Life Science, Chinese Academy of Sciences, Beijing 100101, China. Electronic address: gaof@im.ac.cn. ^[5] West China Hospital Emergency Department (WCHED), State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University, Collaborative Innovation Center of Biotherapy, Chengdu, Sichuan 610041, China. Electronic address: lugw@scu.edu.cn. ^[6]

关键词 antibody-neutralization mechanism crystal structure glycoprotein low-pH-induced structural transition rabies virus transition basis