Global knockout of ROMK potassium channel worsens cardiac ischemia-reperfusion injury but cardiomyocyte-specific knockout does not: Implications for the identity of mitoKATP.

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第一作者： Kyriakos N,Papanicolaou

第一单位： Division of Cardiology, Department of Medicine, The Johns Hopkins University School of Medicine, Baltimore, MD, USA.

作者： Kyriakos N,Papanicolaou ^[1] ; Deepthi,Ashok ^[1] ; Ting,Liu ^[1] ; Tyler M,Bauer ^[2] ; Junhui,Sun ^[2] ; Zhen,Li ^[3] ; Eduardo,da Costa ^[1] ; Charles Crepy,D'Orleans ^[1] ; Sara,Nathan ^[1] ; David J,Lefer ^[3] ; Elizabeth,Murphy ^[2] ; Nazareno,Paolocci ^[4] ; D Brian,Foster ^[1] ; Brian,O'Rourke ^[5]

作者单位： Division of Cardiology, Department of Medicine, The Johns Hopkins University School of Medicine, Baltimore, MD, USA. ^[1] Cardiovascular Branch, NHLBI, NIH, 10 Center Drive, Bethesda, MD, USA. ^[2] Cardiovascular Center of Excellence, Louisiana State University (LSU) Health Sciences Center, New Orleans, LA, USA; Department of Pharmacology and Experimental Therapeutics, LSU Health Sciences Center, New Orleans, LA, USA. ^[3] Division of Cardiology, Department of Medicine, The Johns Hopkins University School of Medicine, Baltimore, MD, USA; Department of Biomedical Sciences, University of Padova, Padova, Italy. ^[4] Division of Cardiology, Department of Medicine, The Johns Hopkins University School of Medicine, Baltimore, MD, USA. Electronic address: bor@jhmi.edu. ^[5]

关键词 Bartter's syndrome Ischemic preconditioning Kcnj1 or Kir1.1 or ROMK Mitochondrial ATP-sensitive potassium channel Mitochondrial permeability transition pore Renal potassium channel