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首页> The Journal of steroid biochemistry and molecular biology> CYP17A1 exhibits 17αhydroxylase/17,20-lyase activity towards 11β-hydroxyprogesterone and 11-ketoprogesterone metabolites in the C11-oxy backdoor pathway.

CYP17A1 exhibits 17αhydroxylase/17,20-lyase activity towards 11β-hydroxyprogesterone and 11-ketoprogesterone metabolites in the C11-oxy backdoor pathway.

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作者： Desmaré,van Rooyen ^[1] ; Rahul,Yadav ^[2] ; Emily E,Scott ^[3] ; Amanda C,Swart ^[4]

作者单位： Biochemistry Department, Stellenbosch University, Stellenbosch 7600, South Africa. ^[1] Medicinal Chemistry Department, University of Michigan, Ann Arbor, MI 48109, United States of America; Department of Chemistry, Mississippi State University, Mississippi State, MS 39762, United States of America. ^[2] Medicinal Chemistry Department, University of Michigan, Ann Arbor, MI 48109, United States of America; Departments of Pharmacology and Biological Chemistry and Biophysics Program, University of Michigan, Ann Arbor, MI 48109, United States of America. ^[3] Biochemistry Department, Stellenbosch University, Stellenbosch 7600, South Africa. Electronic address: acswart@sun.ac.za. ^[4]

关键词 11β-hydroxyandrosterone (11OHAST, 11βOHANDRO)11β-hydroxyetiocholanolone (11βOHETIO)11β-hydroxysteroid dehydrogenase (11βHSD, HSD11B)21-deoxycortisol (21dF)Human cytochrome P450 17α-hydroxylase/17,20-lyase (P450c17)Tetrahydrocortisol (THF)

主题词 3-羰基-5-α-类固醇4-脱氢酶(3-Oxo-5-alpha-Steroid 4-Dehydrogenase);雄激素类(Androgens);细胞系, 肿瘤(Cell Line, Tumor);性腺甾类激素(Gonadal Steroid Hormones);HEK293细胞(HEK293 Cells);人类(Humans);羟孕酮类(Hydroxyprogesterones);男(雄)性(Male);孕酮(Progesterone);前列腺肿瘤(Prostatic Neoplasms);类固醇17-α-羟化酶(Steroid 17-alpha-Hydroxylase);睾酮(Testosterone)

DOI 10.1016/j.jsbmb.2020.105614

PMID 32007561

发布时间 2020-08-12

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The Journal of steroid biochemistry and molecular biology

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