Differentiation of Pathogenic Th17 Cells Is Negatively Regulated by Let-7 MicroRNAs in a Mouse Model of Multiple Sclerosis.

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第一作者： Constance C,Angelou

第一单位： Department of Veterinary and Animal Sciences, University of Massachusetts, Amherst, MA, United States.

作者： Constance C,Angelou ^[1] ; Alexandria C,Wells ^[1] ; Jyothi,Vijayaraghavan ^[1] ; Carey E,Dougan ^[2] ; Rebecca,Lawlor ^[1] ; Elizabeth,Iverson ^[1] ; Vanja,Lazarevic ^[3] ; Motoko Y,Kimura ^[4] ; Shelly R,Peyton ^[2] ; Lisa M,Minter ^[1] ; Barbara A,Osborne ^[1] ; Elena L,Pobezinskaya ^[1] ; Leonid A,Pobezinsky ^[1]

作者单位： Department of Veterinary and Animal Sciences, University of Massachusetts, Amherst, MA, United States. ^[1] Department of Chemical Engineering, University of Massachusetts, Amherst, MA, United States. ^[2] Experimental Immunology Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD, United States. ^[3] Department of Immunology, Graduate School of Medicine, Chiba University, Chiba, Japan. ^[4]

关键词 CCR2 CCR5 CD4 EAE IL-1R1 IL-23R miRNA

主题词动物(Animals);CD4阳性T淋巴细胞(CD4-Positive T-Lymphocytes);细胞分化(Cell Differentiation);细胞因子类(Cytokines);疾病模型, 动物(Disease Models, Animal);疾病易感性(Disease Susceptibility);脑脊髓炎, 自身免疫性, 实验性(Encephalomyelitis, Autoimmune, Experimental);基因表达调控(Gene Expression Regulation);免疫表型分型(Immunophenotyping);淋巴细胞活化(Lymphocyte Activation);小鼠(Mice);微RNAs(MicroRNAs);多发性硬化(Multiple Sclerosis);RNA干扰(RNA Interference);Th17细胞(Th17 Cells)

DOI 10.3389/fimmu.2019.03125

PMID 32010153

发布时间 2023-10-03

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Frontiers in immunology

2019年10卷

3125页

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Differentiation of Pathogenic Th17 Cells Is Negatively Regulated by Let-7 MicroRNAs in a Mouse Model of Multiple Sclerosis.

Frontiers in immunology

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Frontiers in immunology

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Differentiation of Pathogenic Th17 Cells Is Negatively Regulated by Let-7 MicroRNAs in a Mouse Model of Multiple Sclerosis.

Frontiers in immunology

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Frontiers in immunology

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