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首页> BMC immunology> Dysregulation of TNF-α and IFN-γ expression is a common host immune response in a chronically infected mouse model of melioidosis when comparing multiple human strains of Burkholderia pseudomallei.

Dysregulation of TNF-α and IFN-γ expression is a common host immune response in a chronically infected mouse model of melioidosis when comparing multiple human strains of Burkholderia pseudomallei.

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作者： Kei,Amemiya ^[1] ; Jennifer L,Dankmeyer ^[2] ; Jeremy J,Bearss ^[3] ; Xiankun,Zeng ^[3] ; Spencer W,Stonier ^[4] ; Carl,Soffler ^[2] ; Christopher K,Cote ^[2] ; Susan L,Welkos ^[2] ; David P,Fetterer ^[2] ; Taylor B,Chance ^[3] ; Sylvia R,Trevino ^[2] ; Patricia L,Worsham ^[2] ; David M,Waag ^[2]

作者单位： Bacteriology Division, US Army Medical Research Institute of Infectious Diseases, Fort Detrick, Frederick, MD, USA. kei.amemiya.vol@mail.mil. ^[1] Bacteriology Division, US Army Medical Research Institute of Infectious Diseases, Fort Detrick, Frederick, MD, USA. ^[2] Pathology Division, US Army Medical Research Institute of Infectious Diseases, Fort Detrick, Frederick, MD, USA. ^[3] Virology Division, US Army Medical Research Institute of Infectious Diseases, Fort Detrick, Frederick, MD, USA. ^[4]

关键词 BALB/c mice Burkholderia pseudomallei Chronic infection Inflammatory cytokines Intracellular TNFα and IFNγ Pyogranulomatous lesion

主题词动物(Animals);类鼻疽伯霍尔德杆菌(Burkholderia pseudomallei);慢性病(Chronic Disease);疾病模型, 动物(Disease Models, Animal);人类(Humans);免疫, 细胞(Immunity, Cellular);干扰素γ(Interferon-gamma);类鼻疽(Melioidosis);小鼠(Mice);小鼠, 近交BALB C(Mice, Inbred BALB C);脾(Spleen);肿瘤坏死因子α(Tumor Necrosis Factor-alpha)

DOI 10.1186/s12865-020-0333-9

PMID 32013893

发布时间 2020-12-14

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BMC immunology

BMC immunology

2020年21卷1期

5页

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