Andrographolide potentiates PD-1 blockade immunotherapy by inhibiting COX2-mediated PGE2 release.

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作者： Wen,Liu ^[1] ; Ting,Fan ^[1] ; Manru,Li ^[1] ; Guohui,Zhang ^[1] ; Wenjie,Guo ^[1] ; Xiaoling,Yang ^[2] ; Chunhong,Jiang ^[2] ; Xiang,Li ^[1] ; Xiangyu,Xu ^[1] ; Anshu,Tang ^[1] ; Keqin,Liu ^[1] ; Lixuan,Liu ^[1] ; Lingdong,Kong ^[1] ; Qiang,Xu ^[1] ; Yang,Sun ^[3]

作者单位： State Key Laboratory of Pharmaceutical Biotechnology, Department of Biotechnology and Pharmaceutical Sciences, School of Life Science, Nanjing University, 163 Xianlin Avenue, Nanjing 210023, China. ^[1] State Key Laboratory of Innovative Nature Medicine and TCM Injections, Jiangxi Qingfeng Pharmaceutical Co., Ltd., Ganzhou 341000, China. ^[2] State Key Laboratory of Pharmaceutical Biotechnology, Department of Biotechnology and Pharmaceutical Sciences, School of Life Science, Nanjing University, 163 Xianlin Avenue, Nanjing 210023, China; Chemistry and Biomedicine Innovation Center (ChemBIC), Nanjing University, Nanjing 210023, China. Electronic address: yangsun@nju.edu.cn. ^[3]

关键词 Andrographolide Anti-PD-1 COX2 Immnuotherapy PGE2

主题词动物(Animals);细胞系, 肿瘤(Cell Line, Tumor);结肠肿瘤(Colonic Neoplasms);环氧化酶2(Cyclooxygenase 2);地诺前列酮(Dinoprostone);疾病模型, 动物(Disease Models, Animal);二萜类(Diterpenes);女(雌)性(Female);人类(Humans);免疫疗法(Immunotherapy);干扰素γ(Interferon-gamma);小鼠(Mice);小鼠, 近交BALB C(Mice, Inbred BALB C);肿瘤负荷(Tumor Burden);异种移植模型抗肿瘤试验(Xenograft Model Antitumor Assays)

DOI 10.1016/j.intimp.2020.106206

PMID 32018066

发布时间 2021-01-07

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International immunopharmacology

2020年81卷

106206页

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Andrographolide potentiates PD-1 blockade immunotherapy by inhibiting COX2-mediated PGE2 release.

International immunopharmacology

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International immunopharmacology

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Andrographolide potentiates PD-1 blockade immunotherapy by inhibiting COX2-mediated PGE2 release.

International immunopharmacology

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International immunopharmacology

相关期刊

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