Dynamics of the Coreceptor-LCK Interactions during T Cell Development Shape the Self-Reactivity of Peripheral CD4 and CD8 T Cells.

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作者： Veronika,Horkova ^[1] ; Ales,Drobek ^[1] ; Daniel,Mueller ^[2] ; Celine,Gubser ^[3] ; Veronika,Niederlova ^[1] ; Lena,Wyss ^[4] ; Carolyn G,King ^[2] ; Dietmar,Zehn ^[5] ; Ondrej,Stepanek ^[6]

作者单位： Laboratory of Adaptive Immunity, Institute of Molecular Genetics of the Czech Academy of Sciences, 14220 Prague, Czech Republic. ^[1] Department of Biomedicine, University Hospital and University of Basel, 4031 Basel, Switzerland. ^[2] Department of Biomedicine, University Hospital and University of Basel, 4031 Basel, Switzerland; Peter Doherty Institute, University of Melbourne, Melbourne, Australia. ^[3] Department of Biomedicine, University Hospital and University of Basel, 4031 Basel, Switzerland; Institute for Immunology, Biomedical Center (BMC) Munich, Ludwig-Maximilians-University, Munich, Germany. ^[4] Division of Animal Physiology and Immunology, School of Life Sciences Weihenstephan, Technical University of Munich, Freising, Germany. ^[5] Laboratory of Adaptive Immunity, Institute of Molecular Genetics of the Czech Academy of Sciences, 14220 Prague, Czech Republic. Electronic address: ondrej.stepanek@img.cas.cz. ^[6]

关键词 CD4 CD8 LCK T cell TCR evolution of the immune system lymphocyte self-reactivity signaling thymus