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To continue or not to continue? Antipsychotic medication maintenance versus dose-reduction/discontinuation in first episode psychosis: HAMLETT, a pragmatic multicenter single-blind randomized controlled trial.

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第一作者: Marieke J H,Begemann
第一单位: Department of Biomedical Sciences of Cells & Systems, Cognitive Neurosciences, University of Groningen, University Medical Center Groningen (UMCG), Groningen, The Netherlands. m.j.h.begemann@umcg.nl.
作者单位: Department of Biomedical Sciences of Cells & Systems, Cognitive Neurosciences, University of Groningen, University Medical Center Groningen (UMCG), Groningen, The Netherlands. m.j.h.begemann@umcg.nl. [1] Department of Biomedical Sciences of Cells & Systems, Cognitive Neurosciences, University of Groningen, University Medical Center Groningen (UMCG), Groningen, The Netherlands. [2] Department of Psychiatry, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands. [3] Department of Biomedical Sciences of Cells & Systems, Cognitive Neurosciences, University of Groningen, University Medical Center Groningen (UMCG), Groningen, The Netherlands.;Department of Psychiatry, UMC Utrecht Brain Center, University Medical Center Utrecht, Utrecht, The Netherlands. [4] Department of Psychiatry, UMC Utrecht Brain Center, University Medical Center Utrecht, Utrecht, The Netherlands. [5] Parnassia Psychiatric Institute, The Hague, The Netherlands.;Department of Clinical Psychology, VU University, Amsterdam, The Netherlands. [6] Department of Research, Arkin Mental Health Care, Amsterdam, The Netherlands. [7] Department of Psychiatry, UMC Utrecht Brain Center, University Medical Center Utrecht, Utrecht, The Netherlands.;Department of Psychiatry and Neuropsychology, School for Mental Health and Neuroscience, EURON, Maastricht University Medical Center, Maastricht, The Netherlands.;Department of Psychosis Studies, Institute of Psychiatry, Psychology & Neuroscience, King's College London, London, UK. [8] Department of Epidemiology and Biostatistics, Amsterdam Public Health Research Institute, VU University Medical Center, Amsterdam, The Netherlands.;Department of Clinical, Neuro and Developmental Psychology, Amsterdam Public Health Research Institute, VU University Medical Center, Amsterdam, The Netherlands.;Centre of Economic Evaluation, Trimbos Institute (Netherlands Institute of Mental Health), Utrecht, The Netherlands. [9] Lentis Research, Lentis Psychiatric Institute, Groningen, The Netherlands.;Rob Giel Research Center, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands. [10] Early Intervention Psychosis Team, GGZ inGeest Specialized Mental Health Care, Hoofddorp, The Netherlands. [11] Centre for Early Psychosis, Parnassia Psychiatric Institute, The Hague, The Netherlands. [12] Program for Psychosis & Severe Mental Illness, Pro Persona Mental Health, Wolfheze, The Netherlands. [13] Department of Psychiatry, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.;Department of Education and Research, Friesland Mental Health Care Services, Leeuwarden, The Netherlands. [14] Department ABC, Altrecht Psychiatric Institute, Utrecht, The Netherlands. [15] Community Mental Health, Mental Health Service Noord-Holland Noord, Alkmaar, The Netherlands. [16] Early Psychosis Team, GGNet, Apeldoorn, The Netherlands. [17] Center for Youth with Psychosis, Mediant ABC Twente, Enschede, The Netherlands. [18] Department of Psychotic Disorders, GGZ-Drenthe, Assen, The Netherlands. [19] GGZ Delfland, Delfland Institute for Mental Health Care, Delft, The Netherlands. [20] Department of Psychiatry and Neuropsychology, School for Mental Health and Neuroscience, EURON, Maastricht University Medical Center, Maastricht, The Netherlands.;Institute for Mental Health Care Eindhoven (GGzE), Eindhoven, The Netherlands. [21] Reinier van Arkel Institute for Mental Health Care, 's Hertogenbosch, The Netherlands.;Radboud University Medical Centre, Nijmegen, The Netherlands. [22] Yulius, Mental Health Institute, Dordrecht, The Netherlands. [23] Antes Center for Mental Health Care, Rotterdam, The Netherlands.;Department of Neuroscience, Erasmus MC, Rotterdam, The Netherlands.;Department of Psychiatry, Erasmus MC, Rotterdam, The Netherlands. [24] Center for Developmental Disorders, Dimence Institute for Mental Health, Deventer, The Netherlands. [25] Early Intervention Team, GGZ Centraal, Amersfoort, The Netherlands. [26] Department of Psychiatry and Neuropsychology, School for Mental Health and Neuroscience, EURON, Maastricht University Medical Center, Maastricht, The Netherlands.;Mondriaan Mental Health Care, Heerlen, The Netherlands. [27] Emergis, Kenniscentrum, Goes, The Netherlands. [28] Anoiksis, University Medical Center Utrecht, Utrecht, The Netherlands. [29] MIND Ypsilon, Organization of Relatives and Carers of People with a Vulnerability to Psychosis, The Hague, The Netherlands. [30] Department of Early Psychosis, Amsterdam UMC, Academic Medical Center, Amsterdam, The Netherlands. [31]
DOI 10.1186/s13063-019-3822-5
PMID 32033579
发布时间 2024-03-28
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