Impact of the Selective Orexin-1 Receptor Antagonist ACT-539313 on the Pharmacokinetics of the CYP3A Probe Drug Midazolam in Healthy Male Subjects.

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作者： Benjamin,Berger ^[1] ; Priska,Kaufmann ^[1] ; Annelize,Koch ^[2] ; Jasper,Dingemanse ^[1]

作者单位： Department of Clinical Pharmacology, Idorsia Pharmaceuticals Ltd, Allschwil, Switzerland. ^[1] Simbec Research Ltd, Merthyr Tydfil, United Kingdom. ^[2]

关键词 CYP3A cytochrome P450 drug-drug interaction metabolism pharmacokinetics selective orexin-1 receptor antagonist

主题词成年人(Adult);曲线下面积(Area Under Curve);细胞色素P-450 CYP3A(Cytochrome P-450 CYP3A);用药计划表(Drug Administration Schedule);药物相互作用(Drug Interactions);人类(Humans);氢化可的松(Hydrocortisone);男(雄)性(Male);咪达唑仑(Midazolam);中年人(Middle Aged);青年人(Young Adult)

DOI 10.1002/jcph.1588

PMID 32035014

发布时间 2021-06-25

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Journal of clinical pharmacology

2020年60卷7期

931-941页

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Impact of the Selective Orexin-1 Receptor Antagonist ACT-539313 on the Pharmacokinetics of the CYP3A Probe Drug Midazolam in Healthy Male Subjects.

Journal of clinical pharmacology

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Journal of clinical pharmacology

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Impact of the Selective Orexin-1 Receptor Antagonist ACT-539313 on the Pharmacokinetics of the CYP3A Probe Drug Midazolam in Healthy Male Subjects.

Journal of clinical pharmacology

相似文献

Journal of clinical pharmacology

相关期刊

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