Study of the interaction between a novel, protein-stabilizing dipeptide and Interferon-alpha-2a by construction of a Markov state model from molecular dynamics simulations.

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第一作者： Andreas,Tosstorff

第一单位： Department of Pharmacy, Pharmaceutical Technology and Biopharmaceutics, Ludwig-Maximilians-Universität München, Munich, Germany. Electronic address: andreas.tosstorff@cup.uni-muenchen.de.

作者： Andreas,Tosstorff ^[1] ; Günther H J,Peters ^[2] ; Gerhard,Winter ^[3]

作者单位： Department of Pharmacy, Pharmaceutical Technology and Biopharmaceutics, Ludwig-Maximilians-Universität München, Munich, Germany. Electronic address: andreas.tosstorff@cup.uni-muenchen.de. ^[1] Department of Chemistry, Technical University of Denmark, 2800 Kgs. Lyngby, Denmark. ^[2] Department of Pharmacy, Pharmaceutical Technology and Biopharmaceutics, Ludwig-Maximilians-Universität München, Munich, Germany. ^[3]

关键词 Excipient Interferon-alpha-2a Markov state model Protein aggregation Protein formulation

主题词结合部位(Binding Sites);二肽类(Dipeptides);辅药(Excipients);Markov链(Markov Chains);分子动力学模拟(Molecular Dynamics Simulation)

DOI 10.1016/j.ejpb.2020.01.020

PMID 32035237

发布时间 2020-11-30

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