Progress toward the development of the small molecule equivalent of small interfering RNA.

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作者： Matthew D,Disney ^[1] ; Blessy M,Suresh ^[2] ; Raphael I,Benhamou ^[2] ; Jessica L,Childs-Disney ^[2]

作者单位： Scripps Research, Department of Chemistry, 110 Scripps Way, Jupiter, FL, 33458, USA. Electronic address: disney@scripps.edu. ^[1] Scripps Research, Department of Chemistry, 110 Scripps Way, Jupiter, FL, 33458, USA. ^[2]

关键词 Antisense oligonucleotides Non-coding RNA Nucleic acids RNA Ribonuclease targeting chimeras (RIBOTACs)Targeted degradation siRNA

主题词碱基序列(Base Sequence);博来霉素(Bleomycin);药物设计(Drug Design);药物评价, 临床前(Drug Evaluation, Preclinical);基因组(Genome);人类(Humans);分子靶向治疗(Molecular Targeted Therapy);突变(Mutation);核酸构象(Nucleic Acid Conformation);RNA稳定性(RNA Stability);RNA, 小分子干扰(RNA, Small Interfering);小分子化合物库(Small Molecule Libraries);构效关系(Structure-Activity Relationship)

DOI 10.1016/j.cbpa.2020.01.001

PMID 32036231

发布时间 2023-09-29

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Current opinion in chemical biology

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Progress toward the development of the small molecule equivalent of small interfering RNA.

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Progress toward the development of the small molecule equivalent of small interfering RNA.

Current opinion in chemical biology

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Current opinion in chemical biology

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