Phosphoglycerate dehydrogenase promotes proliferation and bortezomib resistance through increasing reduced glutathione synthesis in multiple myeloma.

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作者： Xuan,Wu ^[1] ; Jiliang,Xia ^[2] ; Jingyu,Zhang ^[1] ; Yinghong,Zhu ^[2] ; Yangbowen,Wu ^[2] ; Jiaojiao,Guo ^[2] ; Shilian,Chen ^[3] ; Qian,Lei ^[2] ; Bin,Meng ^[2] ; Chunmei,Kuang ^[2] ; Xiangling,Feng ^[2] ; Yanjuan,He ^[2] ; Yi,Shen ^[3] ; Xin,Li ^[1] ; Lugui,Qiu ^[4] ; Guancheng,Li ^[5] ; Wen,Zhou ^[6]

作者单位： Department of Hematology, Xiangya Hospital, Central South University, Changsha, Hunan, China. ^[1] Key Laboratory of Carcinogenesis of the Chinese Ministry of Health and the Key Laboratory of Carcinogenesis and Cancer Invasion of Chinese Ministry of Education, Cancer Research Institute, School of Basic Medical Sciences, Central South University, Changsha, Hunan, China. ^[2] Xiangya School of Public Health, Central South University, Changsha, Hunan, China. ^[3] Department of Orthopaedic Surgery, Second Xiangya Hospital, Central South University, Changsha, Hunan, China. ^[4] Department of Hematology, Third Xiangya Hospital, Central South University, Changsha, Hunan, China. ^[5] State Key Laboratory of Experimental Hematology, Institute of Hematology and Blood Diseases Hospital, Chinese Academy of Medical Science & Peking Union Medical College, Tianjin, China. ^[6]

关键词 GSH PHGDH bortezomib multiple myeloma serine