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Liver fibrosis and CD206<sup>+</sup> macrophage accumulation are suppressed by anti-GM-CSF therapy.

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第一作者： Alfonso,Tan-Garcia

第一单位： Program in Emerging Infectious Diseases, Duke-NUS Medical School, 8 College Road, Singapore 169857, Singapore.

作者： Alfonso,Tan-Garcia ^[1] ; Fritz,Lai ^[2] ; Joe Poh,Sheng Yeong ^[3] ; Sergio E,Irac ^[1] ; Pei Y,Ng ^[4] ; Rasha,Msallam ^[4] ; Jeffrey Chun,Tatt Lim ^[3] ; Lu-En,Wai ^[1] ; Christine Y L,Tham ^[1] ; Su P,Choo ^[5] ; Tony,Lim ^[3] ; Dan Y,Young ^[6] ; Roberta,D'Ambrosio ^[7] ; Elisabetta,Degasperi ^[7] ; Riccardo,Perbellini ^[7] ; Evan,Newell ^[8] ; Nina,Le Bert ^[1] ; Florent,Ginhoux ^[4] ; Antonio,Bertoletti ^[9] ; Qingfeng,Chen ^[10] ; Charles-Antoine,Dutertre ^[9]

作者单位： Program in Emerging Infectious Diseases, Duke-NUS Medical School, 8 College Road, Singapore 169857, Singapore. ^[1] Humanised Mouse Unit, Institute of Molecular and Cell Biology, ASTAR, 61 Biopolis Drive, Singapore 138673, Singapore. ^[2] Department of Anatomical Pathology, Singapore General Hospital, Singapore. ^[3] Singapore Immunology Network, ASTAR, 8A Biomedical Grove, Immunos Building, Level 4, Singapore 138648, Singapore. ^[4] Department of Medical Oncology, National Cancer Centre, Singapore. ^[5] Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore; Division of Gastroenterology and Hepatology, National University Hospital, National University Health System, Singapore. ^[6] CRC "A.M. e A. Migliavacca" Center for the Study of Liver Disease, Division of Gastroenterology and Hepatology, Fondazione IRCCS Ca' Granda - Ospedale Maggiore Policlinico, Milan, Italy. ^[7] Singapore Immunology Network, ASTAR, 8A Biomedical Grove, Immunos Building, Level 4, Singapore 138648, Singapore.;Fred Hutch Cancer Research Center, Vaccine and Infectious Disease Division, Seattle, WA, USA. ^[8] Program in Emerging Infectious Diseases, Duke-NUS Medical School, 8 College Road, Singapore 169857, Singapore.;Singapore Immunology Network, ASTAR, 8A Biomedical Grove, Immunos Building, Level 4, Singapore 138648, Singapore. ^[9] Humanised Mouse Unit, Institute of Molecular and Cell Biology, ASTAR, 61 Biopolis Drive, Singapore 138673, Singapore.;Department of Physiology, Yong Loo Lin School of Medicine, National University of Singapore, 119228, Singapore. ^[10]

关键词 ALT, alanine aminotransferase BAMBI, BMP and Activin Membrane-bound Inhibitor CD206+ macrophages DAA, direct-acting antiviral DC, dendritic cell FFPE, formalin-fixed paraffin-embedded GM-CSF GM-CSF, granulocyte-macrophage colony-stimulating factor HCC, hepatocellular carcinoma HCV HIER, heat-induced epitope retrieval HSC, hepatic stellate cells ICS, intracellular cytokine staining Intrahepatic macrophages LPS, lipopolysaccharide LSM, liver stiffness measurement MS, multiple sclerosis NASH NASH, non-alcoholic steatohepatitis PBMCs, peripheral blood mononuclear cells RA, rheumatoid arthritis SVR, sustained virological response TCR, T cell receptor TMA, tissue microarray TNFα, tumour necrosis factor-α TSA, tyramide signal amplification anti-GM-CSF neutralizing antibody fibrosis moMΦs, monocyte-derived macrophage-like cells t-SNE, t-distributed stochastic neighbour embedding

DOI 10.1016/j.jhepr.2019.11.006

PMID 32039403

发布时间 2022-04-12

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Liver fibrosis and CD206<sup>+</sup> macrophage accumulation are suppressed by anti-GM-CSF therapy.

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Liver fibrosis and CD206<sup>+</sup> macrophage accumulation are suppressed by anti-GM-CSF therapy.

JHEP reports

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