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首页> European journal of pharmacology> Beta-sitosterol attenuates insulin resistance in adipose tissue via IRS-1/Akt mediated insulin signaling in high fat diet and sucrose induced type-2 diabetic rats.

Beta-sitosterol attenuates insulin resistance in adipose tissue via IRS-1/Akt mediated insulin signaling in high fat diet and sucrose induced type-2 diabetic rats.

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作者： Shyamaladevi,Babu ^[1] ; Madhan,Krishnan ^[1] ; Ponnulakshmi,Rajagopal ^[2] ; Vijayalakshmi,Periyasamy ^[3] ; Vishnupriya,Veeraraghavan ^[1] ; Ramajayam,Govindan ^[4] ; Selvaraj,Jayaraman ^[5]

作者单位： Department of Biochemistry, Saveetha Dental College and Hospitals, Saveetha Institute of Medical and Technical Sciences, Saveetha University, Chennai, Tamil Nadu, India. ^[1] Central Research Laboratory, Meenakshi Academy of Higher Education and Research (Deemed to be University), Chennai, Tamil Nadu, India. ^[2] Department of Biotechnology and Bioinformatics, Holy Cross College, Trichy, Tamilnadu, India. ^[3] Multi Disciplinary Research Unit, Madurai Medical College, TamilNadu, India. ^[4] Department of Biochemistry, Saveetha Dental College and Hospitals, Saveetha Institute of Medical and Technical Sciences, Saveetha University, Chennai, Tamil Nadu, India. Electronic address: jselvaendo@gmail.com. ^[5]

关键词 High fat diet IRS-1/Akt signaling Insulin resistance Molecular dynamics Type-2 diabetes β- Sitosterol

主题词脂肪组织(Adipose Tissue);动物(Animals);计算机模拟(Computer Simulation);糖尿病, 2型(Diabetes Mellitus, Type 2);胰岛素(Insulin);胰岛素受体底物蛋白质类(Insulin Receptor Substrate Proteins);胰岛素抗药性(Insulin Resistance);男(雄)性(Male);模型, 分子(Models, Molecular);分子动力学模拟(Molecular Dynamics Simulation);原癌基因蛋白质c-akt(Proto-Oncogene Proteins c-akt);大鼠(Rats);大鼠, Wistar(Rats, Wistar);信号传导(Signal Transduction);谷甾醇(Sitosterols);蔗糖(Sucrose);src族激酶类(src-Family Kinases)

DOI 10.1016/j.ejphar.2020.173004

PMID 32045603

发布时间 2020-11-27

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European journal of pharmacology

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