换一批Nasal timosaponin BII dually sensitive in situ hydrogels for the prevention of Alzheimer's disease induced by lipopolysaccharides.
第一作者：
Wenyuan,Chen
第一单位：
Department of Pharmaceutical Sciences, Beijing Institute of Radiation Medicine, Beijing 100850, China; School of Medicine, Shandong University of Traditional Chinese Medicine, Jinan 250355, China.
作者：
关键词
Alzheimer’s diseaseBrain targetingChlorobutanol PubChem CID (PubChem CID: 5977)Ethylparaben (PubChem CID: 23681179)Hydroxypropyl-β-cyclodextrin (HP-β-CD) (PubChem CID: 14049689)In situ hydrogelLipopolysaccharide (PubChem CID: 11970143)Methyl hydroxybenzoate (PubChem CID: 7456)Nasal deliveryPoloxamer (PubChem CID: 24751)Sodium alginate (PubChem CID: 133126842)Sulfobutyl ether-β-cyclodextrin (SE-β-CD) (PubChem CID: 66577045)Timosaponin BIITimosaponin BII (PubChem CID: 44575945)β-cyclodextrin (β-CD) (PubChem CID: 53486154)
主题词
投药, 鼻内(Administration, Intranasal);阿尔茨海默病(Alzheimer Disease);动物(Animals);无尾目(Anura);细胞系, 肿瘤(Cell Line, Tumor);女(雌)性(Female);水凝胶类(Hydrogels);白细胞介素1β(Interleukin-1beta);脂多糖类(Lipopolysaccharides);男(雄)性(Male);小鼠(Mice);小鼠, 近交C57BL(Mice, Inbred C57BL);一氧化氮合酶Ⅱ型(Nitric Oxide Synthase Type II);鼻(Nose);PC12细胞(PC12 Cells);兔(Rabbits);大鼠(Rats);皂苷类(Saponins);绵羊(Sheep);甾类(Steroids);肿瘤坏死因子α(Tumor Necrosis Factor-alpha)
DOI
10.1016/j.ijpharm.2020.119115
PMID
32045690
发布时间
2020-11-30
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