首页> Acta pharmacologica Sinica> A novel derivative of valepotriate inhibits the PI3K/AKT pathway and causes Noxa-dependent apoptosis in human pancreatic cancer cells.

A novel derivative of valepotriate inhibits the PI3K/AKT pathway and causes Noxa-dependent apoptosis in human pancreatic cancer cells.

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第一作者： You-You,Yan

第一单位： Department of Clinical Pharmacology, Key Laboratory of Clinical Cancer Pharmacology and Toxicology Research of Zhejiang Province, Hangzhou First People's Hospital, Zhejiang Chinese Medical University, Hangzhou, 310006, China.;Translational Medicine Research Center, Affiliated Hangzhou First People's Hospital, Zhejiang University School of Medicine, Hangzhou, 310006, China.

作者： You-You,Yan ^[1] ; Ke-Yu,Shi ^[2] ; Fei,Teng ^[2] ; Jing,Chen ^[3] ; Jin-Xin,Che ^[4] ; Xiao-Wu,Dong ^[4] ; Neng-Ming,Lin ^[5] ; Bo,Zhang ^[6]

作者单位： Department of Clinical Pharmacology, Key Laboratory of Clinical Cancer Pharmacology and Toxicology Research of Zhejiang Province, Hangzhou First People's Hospital, Zhejiang Chinese Medical University, Hangzhou, 310006, China.;Translational Medicine Research Center, Affiliated Hangzhou First People's Hospital, Zhejiang University School of Medicine, Hangzhou, 310006, China. ^[1] Department of Clinical Pharmacology, Key Laboratory of Clinical Cancer Pharmacology and Toxicology Research of Zhejiang Province, Hangzhou First People's Hospital, Zhejiang Chinese Medical University, Hangzhou, 310006, China.;Translational Medicine Research Center, Affiliated Hangzhou First People's Hospital, Zhejiang University School of Medicine, Hangzhou, 310006, China.;College of Pharmaceutical Sciences, Zhejiang Chinese Medical University, Hangzhou, 311402, China. ^[2] College of Pharmaceutical Sciences, Zhejiang Chinese Medical University, Hangzhou, 311402, China. ^[3] ZJU-ENS Joint Laboratory of Medicinal Chemistry, Zhejiang Province Key Laboratory of Anti-Cancer Drug Research, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, 310058, China. ^[4] Department of Clinical Pharmacology, Key Laboratory of Clinical Cancer Pharmacology and Toxicology Research of Zhejiang Province, Hangzhou First People's Hospital, Zhejiang Chinese Medical University, Hangzhou, 310006, China. lnm1013@zju.edu.cn.;Translational Medicine Research Center, Affiliated Hangzhou First People's Hospital, Zhejiang University School of Medicine, Hangzhou, 310006, China. lnm1013@zju.edu.cn.;College of Pharmaceutical Sciences, Zhejiang Chinese Medical University, Hangzhou, 311402, China. lnm1013@zju.edu.cn. ^[5] Department of Clinical Pharmacology, Key Laboratory of Clinical Cancer Pharmacology and Toxicology Research of Zhejiang Province, Hangzhou First People's Hospital, Zhejiang Chinese Medical University, Hangzhou, 310006, China. zhangbohzss@163.com.;Translational Medicine Research Center, Affiliated Hangzhou First People's Hospital, Zhejiang University School of Medicine, Hangzhou, 310006, China. zhangbohzss@163.com. ^[6]

关键词 Mcl-1 Noxa PI3K/AKT human pancreatic cancer valepotriate