Myeloperoxidase and Septic Conditions Disrupt Sphingolipid Homeostasis in Murine Brain Capillaries In Vivo and Immortalized Human Brain Endothelial Cells In Vitro.

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第一作者： Madeleine,Goeritzer

第一单位： Division of Molecular Biology and Biochemistry, Gottfried Schatz Research Center, Medical University of Graz, Graz 8010, Austria.;BioTechMed-Graz, Graz 8010, Austria.

作者： Madeleine,Goeritzer ^[1] ; Eva,Bernhart ^[2] ; Ioanna,Plastira ^[2] ; Helga,Reicher ^[2] ; Christina,Leopold ^[2] ; Thomas O,Eichmann ^[3] ; Gerald,Rechberger ^[3] ; Corina T,Madreiter-Sokolowski ^[4] ; Jürgen,Prasch ^[2] ; Philipp,Eller ^[5] ; Wolfgang F,Graier ^[2] ; Dagmar,Kratky ^[1] ; Ernst,Malle ^[2] ; Wolfgang,Sattler ^[6]

作者单位： Division of Molecular Biology and Biochemistry, Gottfried Schatz Research Center, Medical University of Graz, Graz 8010, Austria.;BioTechMed-Graz, Graz 8010, Austria. ^[1] Division of Molecular Biology and Biochemistry, Gottfried Schatz Research Center, Medical University of Graz, Graz 8010, Austria. ^[2] BioTechMed-Graz, Graz 8010, Austria.;Institute of Molecular Biosciences, University of Graz, Graz 8010, Austria.;Center for Explorative Lipidomics, BioTechMed-Graz, Graz 8010, Austria. ^[3] Division of Molecular Biology and Biochemistry, Gottfried Schatz Research Center, Medical University of Graz, Graz 8010, Austria.;Department of Health Sciences and Technology, ETH Zurich, Schwerzenbach 8603, Switzerland. ^[4] Department of Internal Medicine, Intensive Care Unit, Medical University of Graz, Graz 8036, Austria. ^[5] Division of Molecular Biology and Biochemistry, Gottfried Schatz Research Center, Medical University of Graz, Graz 8010, Austria.;BioTechMed-Graz, Graz 8010, Austria.;Center for Explorative Lipidomics, BioTechMed-Graz, Graz 8010, Austria. ^[6]

关键词 blood–brain barrier calorimetry ceramides cytokines fatty acid mitochondrial function myeloperoxidase sphingomyelins