The intermediate proteasome is constitutively expressed in pancreatic beta cells and upregulated by stimulatory, low concentrations of interleukin 1 β.
第一作者:
Muhammad Saad,Khilji
第一单位:
Laboratory of Immuno-endocrinology, Inflammation, Metabolism and Oxidation Section, Department of Biomedical Sciences, University of Copenhagen, Copenhagen, Denmark.;Department of Physiology, University of Veterinary and Animal Sciences, Lahore, Punjab, Pakistan.
作者:
医学主题词
动物(Animals);自身抗原(Autoantigens);糖尿病, 1型(Diabetes Mellitus, Type 1);组织相容性抗原Ⅰ类(Histocompatibility Antigens Class I);人类(Humans);胰岛素分泌细胞(Insulin-Secreting Cells);白细胞介素1β(Interleukin-1beta);Jurkat细胞(Jurkat Cells);小鼠(Mice);胰岛素原(Proinsulin);蛋白酶体内肽酶复合物(Proteasome Endopeptidase Complex);增量调节(Up-Regulation)
DOI
10.1371/journal.pone.0222432
PMID
32053590
发布时间
2020-05-11
- 浏览3
PloS one
e0222432页
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