Longitudinal effects of clozapine concentration and clozapine to N-desmethylclozapine ratio on cognition: A mediation model.

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第一作者： Francesco,Dal Santo

第一单位： Servicio de Salud del Principado de Asturias (SESPA), Oviedo, Spain; Área de Psiquiatría, Universidad de Oviedo, Oviedo, Spain; Instituto de Investigación Sanitaria del Principado de Asturias (ISPA), Oviedo, Spain; Instituto de Neurociencias del Principado de Asturias (INEUROPA), Oviedo, Spain; Department of Psychiatry and Behavioural and Clinical Neuroscience Institute, University of Cambridge, Cambridge, UK.

作者： Francesco,Dal Santo ^[1] ; Isaac,Jarratt-Barnham ^[2] ; Leticia,González-Blanco ^[3] ; María Paz,García-Portilla ^[3] ; Julio,Bobes ^[3] ; Emilio,Fernández-Egea ^[4]

作者单位： Servicio de Salud del Principado de Asturias (SESPA), Oviedo, Spain; Área de Psiquiatría, Universidad de Oviedo, Oviedo, Spain; Instituto de Investigación Sanitaria del Principado de Asturias (ISPA), Oviedo, Spain; Instituto de Neurociencias del Principado de Asturias (INEUROPA), Oviedo, Spain; Department of Psychiatry and Behavioural and Clinical Neuroscience Institute, University of Cambridge, Cambridge, UK. ^[1] Department of Psychiatry and Behavioural and Clinical Neuroscience Institute, University of Cambridge, Cambridge, UK. ^[2] Servicio de Salud del Principado de Asturias (SESPA), Oviedo, Spain; Área de Psiquiatría, Universidad de Oviedo, Oviedo, Spain; Instituto de Investigación Sanitaria del Principado de Asturias (ISPA), Oviedo, Spain; Instituto de Neurociencias del Principado de Asturias (INEUROPA), Oviedo, Spain; Centro de Investigación Biomédica en Red de Salud Mental (CIBERSAM), Spain. ^[3] Department of Psychiatry and Behavioural and Clinical Neuroscience Institute, University of Cambridge, Cambridge, UK; Cambridgeshire and Peterborough NHS Foundation Trust, 128 Tenison Road, CB1 2DP Cambridge, UK. Electronic address: ef280@cam.ac.uk. ^[4]

关键词 Clozapine Cognitive dysfunction N-desmethylclozapine Psychotic disorders Schizophrenia