首页> International journal of pharmaceutics> Drug recrystallization in drug-in-adhesive transdermal delivery system: A case study of deteriorating the mechanical and rheological characteristics of testosterone TDS.

Drug recrystallization in drug-in-adhesive transdermal delivery system: A case study of deteriorating the mechanical and rheological characteristics of testosterone TDS.

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第一作者： Loqman A,Mohamed

第一单位： Division of Pharmaceutical Manufacturing II, Office of Pharmaceutical Manufacturing Assessment, Office of Pharmaceutical Quality, Center for Drug Evaluation and Research, Food and Drug Administration, Maryland, USA.

作者： Loqman A,Mohamed ^[1] ; Nahid,Kamal ^[2] ; Khaled H,Elfakhri ^[2] ; Daniel,Willett ^[3] ; Anna,Wokovich ^[3] ; Caroline,Strasinger ^[4] ; Celia N,Cruz ^[2] ; Sam G,Raney ^[5] ; Muhammad,Ashraf ^[2] ; Ahmed S,Zidan ^[6]

作者单位： Division of Pharmaceutical Manufacturing II, Office of Pharmaceutical Manufacturing Assessment, Office of Pharmaceutical Quality, Center for Drug Evaluation and Research, Food and Drug Administration, Maryland, USA. ^[1] Division of Product Quality Research, Office of Testing and Research, Office of Pharmaceutical Quality, Center for Drug Evaluation and Research, Food and Drug Administration, Maryland, USA. ^[2] Division of Pharmaceutical Analysis, Office of Testing and Research, Office of Pharmaceutical Quality, Center for Drug Evaluation and Research, Food and Drug Administration, MO, USA. ^[3] Division of New Drug Products II, Office of New Drug Products, Office of Pharmaceutical Quality, Center for Drug Evaluation and Research, Food and Drug Administration, Maryland, USA. ^[4] Office of Research and Standards, Office of Generic Drugs, Center for Drug Evaluation and Research, Food and Drug Administration, Silver Spring, MD, USA. ^[5] Division of Product Quality Research, Office of Testing and Research, Office of Pharmaceutical Quality, Center for Drug Evaluation and Research, Food and Drug Administration, Maryland, USA. Electronic address: Ahmed.Zidan@fda.hhs.gov. ^[6]

关键词 Adhesion Crystallization Drug release Permeation Testosterone Transdermal delivery system