换一批
换一批TMEM16A Ca<sup>2+</sup>-activated Cl<sup>-</sup> channel inhibition ameliorates acute pancreatitis via the IP<sub>3</sub>R/Ca<sup>2+</sup>/NFκB/IL-6 signaling pathway.
作者：
关键词
AP, acute pancreatitisAcute pancreatitisBAPTA-AM, 1,2-bis(2-aminophenoxy)ethane-N,N,N′,N′-tetraacetic acid-acetyloxymethyl esterCCK, cholesystokininCFBE, cystic fibrosis bronchial epithelialCaCCinh-A01, Ca2+-activated Cl? channel inhibitor-A01EDTA, ethylenediaminetetraacetic acidEGF, epidermal growth factorEGFP, green fluorescent proteinEGFR, epidermal growth factor receptorEGTA, ethylene glycol-bis(2-aminoethyl ether)-N,N,N',N'-tetraacetic acidELISA, enzyme-linked immunosorbent assayER, endoplasmic reticulumFBS, fetal bovine serumHEPES, N-2-hydroxyethil-piperazine-N'-2-ethanesulfonic acidIL-6, interleukin 6IL-6R, interleukin 6 receptorIP3R, inositol 1,4,5-trisphosphate receptorInositol 1,4,5-trisphosphate receptorInterleukin-6NFκBNFκB, nuclear factor-κBNMDG, N-methyl-D-glucamineNP-40, Nonidet P-40PACs, pancreatic acinar cellsRIPA, radio immunoprecipitation assaySDS-PAGE, sodium dodecyl sulfate polyacrylamide gel electrophoresisSTAT3, signal transducers and activators of transcription 3T16Ainh-A01, TMEM16A inhibitor-A01TMEM16ATris, tris(hydroxymethyl)aminomethaneWT, wild typeshRNAs, short hairpin RNAs
DOI
10.1016/j.jare.2020.01.006
PMID
32071789
发布时间
2020-09-28
- 浏览2
Journal of advanced research
2020年23卷
25-35页
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