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Redox lipid reprogramming commands susceptibility of macrophages and microglia to ferroptotic death.

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作者单位: Department of Environmental and Occupational Health and Center for Free Radical and Antioxidant Health University of Pittsburgh, Pittsburgh, PA, USA. [1] Department of Critical Care Medicine, Safar Center for Resuscitation Research, Children's Neuroscience Institute, Children's Hospital of Pittsburgh, University of Pittsburgh, Pittsburgh, PA, USA. [2] The Wistar Institute, Philadelphia, PA, USA. [3] Institute for Immunology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA. [4] Department of Cell Biology, Pittsburgh, University of Pittsburgh, Pittsburgh, PA, USA. [5] Department of Computational and Systems Biology, Pittsburgh, University of Pittsburgh, Pittsburgh, PA, USA. [6] Institute of Physics, Faculty of Physics Astronomy and Informatics, Nicolaus Copernicus University in Toruń, Toruń, Poland. [7] Department of Developmental Biology, Rangos Research Center of Children's Hospital of Pittsburgh, University of Pittsburgh, Pittsburgh, PA, USA. [8] Laboratory of Navigational Redox Lipidomics, Institute for Regenerative Medicine, IM Sechenov Moscow State Medical University, Moscow, Russia. [9] Mass Spectrometry Center, QOPNA, University of Aveiro, Aveiro, Portugal. [10] Department of Chemistry and CESAM&ECOMARE, University of Aveiro, Aveiro, Portugal. [11] Department of Radiation Oncology, University of Pittsburgh, Pittsburgh, PA, USA. [12] Department of Internal Medicine, The Ohio State University, Columbus, OH, USA. [13] The Wistar Institute, Philadelphia, PA, USA. dgabrilovich@Wistar.org. [14] Department of Environmental and Occupational Health and Center for Free Radical and Antioxidant Health University of Pittsburgh, Pittsburgh, PA, USA. bayihx@ccm.upmc.edu. [15] Department of Critical Care Medicine, Safar Center for Resuscitation Research, Children's Neuroscience Institute, Children's Hospital of Pittsburgh, University of Pittsburgh, Pittsburgh, PA, USA. bayihx@ccm.upmc.edu. [16] Department of Environmental and Occupational Health and Center for Free Radical and Antioxidant Health University of Pittsburgh, Pittsburgh, PA, USA. kagan@pitt.edu. [17] Laboratory of Navigational Redox Lipidomics, Institute for Regenerative Medicine, IM Sechenov Moscow State Medical University, Moscow, Russia. kagan@pitt.edu. [18] Department of Radiation Oncology, University of Pittsburgh, Pittsburgh, PA, USA. kagan@pitt.edu. [19] Department of Chemistry, Pittsburgh, University of Pittsburgh, Pittsburgh, PA, USA. kagan@pitt.edu. [20] Department of Pharmacology and Chemical Biology, Pittsburgh, University of Pittsburgh, Pittsburgh, PA, USA. kagan@pitt.edu. [21]
DOI 10.1038/s41589-019-0462-8
PMID 32080625
发布时间 2024-04-25
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