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Downregulation of Siah1 promotes colorectal cancer cell proliferation and migration by regulating AKT and YAP ubiquitylation and proteasome degradation.

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第一作者： Zhiyuan,Xiao

第一单位： 1Department of Pathology, Nanfang Hospital and School of Basic Medical Science, Southern Medical University, Guangzhou, 510515 China.;2Guangdong Provincial Key Laboratory of Molecular Tumor Pathology, Guangzhou, China.;3Department of Pathology, Shenzhen People's Hospital, Second Clinical Medical College of Jinan University, Shenzhen, Guangdong China.

作者： Zhiyuan,Xiao ^[1] ; Zhigang,Wei ^[2] ; Danling,Deng ^[3] ; Zhe,Zheng ^[4] ; Yali,Zhao ^[4] ; Shenglu,Jiang ^[4] ; Dan,Zhang ^[4] ; Ling-Jie,Zhang ^[4] ; Mingmei,Fan ^[4] ; Siqi,Chen ^[4] ; ShuYang,Wang ^[4] ; Yanqing,Ding ^[4] ; Yaping,Ye ^[4] ; Hongli,Jiao ^[4]

作者单位： 1Department of Pathology, Nanfang Hospital and School of Basic Medical Science, Southern Medical University, Guangzhou, 510515 China.;2Guangdong Provincial Key Laboratory of Molecular Tumor Pathology, Guangzhou, China.;3Department of Pathology, Shenzhen People's Hospital, Second Clinical Medical College of Jinan University, Shenzhen, Guangdong China. ^[1] 4Department of General Surgery, Nanfang Hospital, Southern Medical University, Guangzhou, China. ^[2] 1Department of Pathology, Nanfang Hospital and School of Basic Medical Science, Southern Medical University, Guangzhou, 510515 China.;2Guangdong Provincial Key Laboratory of Molecular Tumor Pathology, Guangzhou, China.;Department of Pathology, Shaoyang Central Hospital, Affiliated Shaoyang Hospital of University of South China, Shaoyang, Hunan China. ^[3] 1Department of Pathology, Nanfang Hospital and School of Basic Medical Science, Southern Medical University, Guangzhou, 510515 China.;2Guangdong Provincial Key Laboratory of Molecular Tumor Pathology, Guangzhou, China. ^[4]

关键词 Colorectal cancer Migration Proliferation Siah1 Ubiquitylation

DOI 10.1186/s12935-020-1124-3

PMID 32082080

发布时间 2022-04-12

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