TLR8 and complement C5 induce cytokine release and thrombin activation in human whole blood challenged with Gram-positive bacteria.

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第一作者： Birgitta,Ehrnström

第一单位： Centre of Molecular Inflammation Research, Norwegian University of Science and Technology, Trondheim, Norway.

作者： Birgitta,Ehrnström ^[1] ; June F,Kojen ^[2] ; Miriam,Giambelluca ^[3] ; Liv,Ryan ^[1] ; Siv H,Moen ^[2] ; Zhenyi,Hu ^[1] ; Hang,Yin ^[2] ; Tom E,Mollnes ^[1] ; Jan K,Damås ^[2] ; Terje,Espevik ^[1] ; Jørgen,Stenvik ^[2]

作者单位： Centre of Molecular Inflammation Research, Norwegian University of Science and Technology, Trondheim, Norway. ^[1] Department of Clinical and Molecular Medicine, Norwegian University of Science and Technology, Trondheim, Norway. ^[2] Department of Infectious Diseases, Clinic of Medicine, St. Olavs Hospital HF, Trondheim University Hospital, Trondheim, Norway. ^[3] Department of Chemistry and Biochemistry and BioFrontiers Institute, University of Colorado Boulder, Boulder, Colorado, USA. ^[4] School of Pharmaceutical Sciences, Tsinghua University-Peking University Joint Center for Life Sciences, Tsinghua University, Beijing, China. ^[5] Research Laboratory, Nordland Hospital, and K. G. Jebsen TREC, University of Tromsø, Norway. ^[6] Department of Immunology, Oslo University Hospital and K. G. Jebsen IRC, University of Oslo, Oslo, Norway. ^[7]

关键词 bacterial infection blood cytokines innate immunity phagocytes phagocytosis prothrombin