首页> Cancers> Personalized Assessment of Normal Tissue Radiosensitivity via Transcriptome Response to Photon, Proton and Carbon Irradiation in Patient-Derived Human Intestinal Organoids.

Personalized Assessment of Normal Tissue Radiosensitivity via Transcriptome Response to Photon, Proton and Carbon Irradiation in Patient-Derived Human Intestinal Organoids.

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第一作者： Ali,Nowrouzi

第一单位： Heidelberg Ion-Beam Therapy Center (HIT), Department of Radiation Oncology, Heidelberg University Hospital (UKHD), 69120 Heidelberg, Germany.;German Cancer Consortium (DKTK) Core Center, Clinical Cooperation Units (CCU) Translational Radiation Oncology and Radiation Oncology, National Center for Tumor Diseases (NCT), German Cancer Research Center (DKFZ), 69120 Heidelberg, Germany.;Heidelberg Institute of Radiation Oncology (HIRO), National Center for Radiation Research in Oncology (NCRO), German Cancer Research Center (DKFZ) and Heidelberg University Hospital (UKHD), 69120 Heidelberg, Germany.;Division of Molecular and Translational Radiation Oncology, Heidelberg Medical Faculty (HDMF), Heidelberg University, 69120 Heidelberg, Germany.

作者： Ali,Nowrouzi ^[1] ; Mathieu G,Sertorio ^[2] ; Mahdi,Akbarpour ^[1] ; Maximillian,Knoll ^[1] ; Damir,Krunic ^[3] ; Matthew,Kuhar ^[4] ; Christian,Schwager ^[1] ; Stephan,Brons ^[5] ; Jürgen,Debus ^[1] ; Susanne I,Wells ^[2] ; James M,Wells ^[6] ; Amir,Abdollahi ^[1]

作者单位： Heidelberg Ion-Beam Therapy Center (HIT), Department of Radiation Oncology, Heidelberg University Hospital (UKHD), 69120 Heidelberg, Germany.;German Cancer Consortium (DKTK) Core Center, Clinical Cooperation Units (CCU) Translational Radiation Oncology and Radiation Oncology, National Center for Tumor Diseases (NCT), German Cancer Research Center (DKFZ), 69120 Heidelberg, Germany.;Heidelberg Institute of Radiation Oncology (HIRO), National Center for Radiation Research in Oncology (NCRO), German Cancer Research Center (DKFZ) and Heidelberg University Hospital (UKHD), 69120 Heidelberg, Germany.;Division of Molecular and Translational Radiation Oncology, Heidelberg Medical Faculty (HDMF), Heidelberg University, 69120 Heidelberg, Germany. ^[1] Cancer and Blood Diseases Institute, Cincinnati Children's Hospital Medical Center, Cincinnati, OH 45229, USA. ^[2] Light Microscopy Facility, German Cancer Research Center, 69120 Heidelberg, Germany. ^[3] Division of Developmental Biology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH 45229, USA. ^[4] Heidelberg Institute of Radiation Oncology (HIRO), National Center for Radiation Research in Oncology (NCRO), German Cancer Research Center (DKFZ) and Heidelberg University Hospital (UKHD), 69120 Heidelberg, Germany. ^[5] Division of Developmental Biology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH 45229, USA.;Division of Endocrinology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH 45229, USA.;Center for Stem Cell and Organoid Medicine, Cincinnati Children's Hospital Medical Center, Cincinnati, OH 45229, USA. ^[6]

关键词 carbon ions gastrointestinal (GI) toxicity human intestinal organoids (HIO)particle therapy personalized medicine radiotherapy

DOI 10.3390/cancers12020469

PMID 32085439

发布时间 2021-07-20

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