Reduced sialylation triggers homeostatic synapse and neuronal loss in middle-aged mice.

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第一作者： Christine,Klaus

第一单位： Neural Regeneration, Institute of Reconstructive Neurobiology, Medical Faculty and University Hospital of Bonn, University of Bonn, Bonn, Germany.

作者： Christine,Klaus ^[1] ; Jan N,Hansen ^[2] ; Aurélien,Ginolhac ^[3] ; Deborah,Gérard ^[3] ; Vinayaga S,Gnanapragassam ^[4] ; Rüdiger,Horstkorte ^[4] ; Charlotte,Rossdam ^[5] ; Falk F R,Buettner ^[5] ; Thomas,Sauter ^[3] ; Lasse,Sinkkonen ^[3] ; Harald,Neumann ^[6] ; Bettina,Linnartz-Gerlach ^[1]

作者单位： Neural Regeneration, Institute of Reconstructive Neurobiology, Medical Faculty and University Hospital of Bonn, University of Bonn, Bonn, Germany. ^[1] Biophysical Imaging, Institute of Innate Immunity, Medical Faculty, University of Bonn, Bonn, Germany. ^[2] Epigenetics Team, Systems Biology Group, Life Sciences Research Unit, University of Luxembourg, Belvaux, Luxembourg. ^[3] Institute for Physiological Chemistry, Medical Faculty, Martin Luther University Halle-Wittenberg, Halle (Saale), Germany. ^[4] Institute of Clinical Biochemistry, Hannover Medical School, Hannover, Germany. ^[5] Neural Regeneration, Institute of Reconstructive Neurobiology, Medical Faculty and University Hospital of Bonn, University of Bonn, Bonn, Germany. Electronic address: harald.neumann@uni-bonn.de. ^[6]

关键词 Aging GNE Glycocalyx Microglia Neurodegeneration Neuroinflammation Sialic acid