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A pharmacometric approach to define target site-specific breakpoints for bacterial killing and resistance suppression integrating microdialysis, time-kill curves and heteroresistance data: a case study with moxifloxacin.

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第一作者： K,Iqbal

第一单位： Department of Clinical Pharmacy, Institute of Pharmacy, University of Hamburg, Germany.

作者： K,Iqbal ^[1] ; A,Broeker ^[1] ; H,Nowak ^[2] ; T,Rahmel ^[2] ; A,Nussbaumer-Pröll ^[3] ; Z,Österreicher ^[3] ; M,Zeitlinger ^[3] ; S G,Wicha ^[4]

作者单位： Department of Clinical Pharmacy, Institute of Pharmacy, University of Hamburg, Germany. ^[1] Department of Anaesthesiology, Intensive Care Medicine and Pain Therapy, University Hospital Knappschaftskrankenhaus Bochum, Ruhr-University Bochum, Germany. ^[2] Department of Clinical Pharmacology, Medical University of Vienna, Austria. ^[3] Department of Clinical Pharmacy, Institute of Pharmacy, University of Hamburg, Germany. Electronic address: sebastian.wicha@uni-hamburg.de. ^[4]

关键词 Microdialysis Non-linear mixed effects modelling PBPK modelling Pharmacokinetic-pharmacodynamic (PK/PD)Pharmacometric Resistance suppression Target specific breakpoints Time-kill studies