Pancreatic β cell microRNA-26a alleviates type 2 diabetes by improving peripheral insulin sensitivity and preserving β cell function.-论文-万方医学网

作者： Haixia,Xu ^[1] ; Xiao,Du ^[2] ; Jia,Xu ^[3] ; Yu,Zhang ^[1] ; Yan,Tian ^[1] ; Geng,Liu ^[4] ; Xiuxuan,Wang ^[1] ; Meilin,Ma ^[5] ; Wenya,Du ^[1] ; Yu,Liu ^[1] ; Lunzhi,Dai ^[5] ; Wendong,Huang ^[5] ; Nanwei,Tong ^[6] ; Yuquan,Wei ^[7] ; Xianghui,Fu ^[4]

作者单位： Division of Endocrinology and Metabolism, National Clinical Research Center for Geriatrics, State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University and Collaborative Innovation Center of Biotherapy, Chengdu, China. ^[1] Department of Gastrointestinal Surgery, West China Hospital, Sichuan University, Chengdu, China. ^[2] Department of General Surgery, Yaan People's Hospital, Yaan, Sichuan, China. ^[3] State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University and Collaborative Innovation Center of Biotherapy, Chengdu, China. ^[4] Department of General Practice and Lab of PTM, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University and Collaborative Innovation Center of Biotherapy, Chengdu, China. ^[5] Department of Diabetes Complications and Metabolism, Beckman Research Institute of City of Hope, Duarte, California, United States of America. ^[6] Division of Endocrinology and Metabolism, West China Hospital, Sichuan University, Chengdu, China. ^[7]

主题词动物(Animals);细胞增殖(Cell Proliferation);糖尿病, 实验性(Diabetes Mellitus, Experimental);糖尿病, 2型(Diabetes Mellitus, Type 2);外泌体(Exosomes);基因表达(Gene Expression);基因表达调控(Gene Expression Regulation);葡萄糖(Glucose);人类(Humans);高胰岛素血症(Hyperinsulinism);增生(Hyperplasia);胰岛素(Insulin);胰岛素抗药性(Insulin Resistance);胰岛素分泌细胞(Insulin-Secreting Cells);男(雄)性(Male);小鼠(Mice);小鼠, 肥胖(Mice, Obese);小鼠, 转基因(Mice, Transgenic);微RNAs(MicroRNAs);旁分泌细胞细胞间通讯(Paracrine Communication);信号传导(Signal Transduction)

DOI 10.1371/journal.pbio.3000603

PMID 32092075

发布时间 2020-05-14

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Pancreatic β cell microRNA-26a alleviates type 2 diabetes by improving peripheral insulin sensitivity and preserving β cell function.

PLoS biology

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Pancreatic β cell microRNA-26a alleviates type 2 diabetes by improving peripheral insulin sensitivity and preserving β cell function.

PLoS biology

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PLoS biology

相关期刊

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