Ailanthone increases oxidative stress in CDDP-resistant ovarian and bladder cancer cells by inhibiting of Nrf2 and YAP expression through a post-translational mechanism.

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第一作者： Marie Angèle,Cucci

第一单位： Department of Clinical and Biological Science, University of Turin, Corso Raffaello 30, 10125, Torino, Italy.

作者： Marie Angèle,Cucci ^[1] ; Margherita,Grattarola ^[1] ; Chiara,Dianzani ^[2] ; Giovanna,Damia ^[3] ; Francesca,Ricci ^[3] ; Antonella,Roetto ^[1] ; Francesco,Trotta ^[4] ; Giuseppina,Barrera ^[1] ; Stefania,Pizzimenti ^[5]

作者单位： Department of Clinical and Biological Science, University of Turin, Corso Raffaello 30, 10125, Torino, Italy. ^[1] Department of Scienza e Tecnologia del Farmaco, Università di Torino, Via Pietro Giuria 9, 10125, Turin, Italy. ^[2] Istituto di Ricerche Farmacologiche "Mario Negri-IRCCS", Via Mario Negri 2, 20156, Milan, Italy. ^[3] Department of Chemistry, University of Turin, Via Pietro Giuria 7, 10125, Turin, Italy. ^[4] Department of Clinical and Biological Science, University of Turin, Corso Raffaello 30, 10125, Torino, Italy. Electronic address: stefania.pizzimenti@unito.it. ^[5]

关键词 Ailanthone Bladder cancer cells CDDP-Resistance Keap1 Nrf2 Ovarian cancer cells Oxidative stress level Protein degradation Superoxide anion UCHL1 Yap p62/SQSTM1