Targeted Protein Degradation by Chimeric Compounds using Hydrophobic E3 Ligands and Adamantane Moiety.

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作者： Takuji,Shoda ^[1] ; Nobumichi,Ohoka ^[2] ; Genichiro,Tsuji ^[1] ; Takuma,Fujisato ^[1] ; Hideshi,Inoue ^[3] ; Yosuke,Demizu ^[3] ; Mikihiko,Naito ^[1] ; Masaaki,Kurihara ^[2]

作者单位： Division of Organic Chemistry, National Institute of Health Sciences, 3-25-26 Tonomachi, Kawasaki, Kanagawa 210-9501, Japan. ^[1] Division of Molecular Target and Gene Therapy Products, National Institute of Health Sciences, 3-25-26 Tonomachi, Kawasaki, Kanagawa 210-9501, Japan. ^[2] School of Life Sciences, Tokyo University of Pharmacy and Life Sciences, 1432-1 Horinouchi, Hachioji, Tokyo 192-0392, Japan. ^[3]

关键词 adamantane chimeric compound hydrophobic tagging protein degradation

DOI 10.3390/ph13030034

PMID 32106507

发布时间 2020-09-28

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