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首页> Biochemical pharmacology> Dihydromyricetin alleviates doxorubicin-induced cardiotoxicity by inhibiting NLRP3 inflammasome through activation of SIRT1.

Dihydromyricetin alleviates doxorubicin-induced cardiotoxicity by inhibiting NLRP3 inflammasome through activation of SIRT1.

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第一作者： Zhenzhu,Sun

第一单位： The First Clinical Medical College, Wenzhou Medical University, Wenzhou 325000, Zhejiang, China.

作者： Zhenzhu,Sun ^[1] ; Wenqiang,Lu ^[2] ; Na,Lin ^[3] ; Hui,Lin ^[4] ; Jie,Zhang ^[4] ; Tingjuan,Ni ^[2] ; Liping,Meng ^[4] ; Chuanjing,Zhang ^[2] ; Hangyuan,Guo ^[5]

作者单位： The First Clinical Medical College, Wenzhou Medical University, Wenzhou 325000, Zhejiang, China. ^[1] Zhejiang University School of Medicine, Hangzhou, China. ^[2] Zhejiang Chinese Medical University, Hangzhou, China. ^[3] Department of Cardiology, Shaoxing People's Hospital, Shaoxing Hospital of Zhejiang University, Shaoxing 312000, Zhejiang, China. ^[4] The First Clinical Medical College, Wenzhou Medical University, Wenzhou 325000, Zhejiang, China; Department of Cardiology, Shaoxing People's Hospital, Shaoxing Hospital of Zhejiang University, Shaoxing 312000, Zhejiang, China. Electronic address: guohangyuan@zju.edu.cn. ^[5]

关键词 Cardiotoxicity Dihydromyricetin Doxorubicin NLRP3 inflammasome SIRT1

主题词动物(Animals);抗生素类, 抗肿瘤(Antibiotics, Antineoplastic);细胞凋亡(Apoptosis);细胞系(Cell Line);细胞存活(Cell Survival);多柔比星(Doxorubicin);黄酮醇类(Flavonols);心脏(Heart);炎性体(Inflammasomes);男(雄)性(Male);心肌(Myocardium);肌细胞, 心脏(Myocytes, Cardiac);大鼠(Rats);大鼠, Sprague-Dawley(Rats, Sprague-Dawley);抗衰老酶1(Sirtuin 1);心室功能障碍, 左(Ventricular Dysfunction, Left)

DOI 10.1016/j.bcp.2020.113888

PMID 32112883

发布时间 2020-10-29

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Biochemical pharmacology

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