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Systematic identification of engineered methionines and oxaziridines for efficient, stable, and site-specific antibody bioconjugation.

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第一作者： Susanna K,Elledge

第一单位： Department of Pharmaceutical Chemistry, University of California, San Francisco, CA 94158.

作者： Susanna K,Elledge ^[1] ; Hai L,Tran ^[1] ; Alec H,Christian ^[2] ; Veronica,Steri ^[3] ; Byron,Hann ^[3] ; F Dean,Toste ^[2] ; Christopher J,Chang ^[4] ; James A,Wells ^[5]

作者单位： Department of Pharmaceutical Chemistry, University of California, San Francisco, CA 94158. ^[1] Department of Chemistry, University of California, Berkeley, CA 94720. ^[2] Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, CA 94158.;Preclinical Therapeutics Core, University of California, San Francisco, CA 94158. ^[3] Department of Chemistry, University of California, Berkeley, CA 94720.;Department of Molecular and Cell Biology, University of California, Berkeley, CA 94720.;Howard Hughes Medical Institute, University of California, Berkeley, CA 94720. ^[4] Department of Pharmaceutical Chemistry, University of California, San Francisco, CA 94158; jim.wells@ucsf.edu.;Department of Cellular and Molecular Pharmacology, University of California, San Francisco, CA 94158. ^[5]

关键词 antibody drug conjugate bioconjugation chemical biology oxaziridine methionine chemistry protein engineering