首页> Proceedings of the National Academy of Sciences of the United States of America> Lactate dehydrogenase inhibition synergizes with IL-21 to promote CD8<sup>+</sup> T cell stemness and antitumor immunity.

Lactate dehydrogenase inhibition synergizes with IL-21 to promote CD8<sup>+</sup> T cell stemness and antitumor immunity.

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第一作者： Dalton,Hermans

第一单位： Laboratory of Molecular Immunology and the Immunology Center, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20892.

作者： Dalton,Hermans ^[1] ; Sanjivan,Gautam ^[2] ; Juan C,García-Cañaveras ^[3] ; Daniel,Gromer ^[1] ; Suman,Mitra ^[1] ; Rosanne,Spolski ^[1] ; Peng,Li ^[1] ; Stephen,Christensen ^[1] ; Rosa,Nguyen ^[1] ; Jian-Xin,Lin ^[1] ; Jangsuk,Oh ^[1] ; Ning,Du ^[1] ; Sharon,Veenbergen ^[1] ; Jessica,Fioravanti ^[2] ; Risa,Ebina-Shibuya ^[1] ; Christopher,Bleck ^[4] ; Leonard M,Neckers ^[5] ; Joshua D,Rabinowitz ^[3] ; Luca,Gattinoni ^[6] ; Warren J,Leonard ^[7]

作者单位： Laboratory of Molecular Immunology and the Immunology Center, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20892. ^[1] Experimental Transplantation and Immunology Branch, Center for Cancer Research, National Cancer Institute, Bethesda, MD 20892. ^[2] Department of Chemistry, Princeton University, Princeton, NJ 08540.;Lewis-Sigler Institute, Princeton University, Princeton, NJ 08540. ^[3] Electron Microscopy Core Facility, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20892. ^[4] Urologic Oncology Branch, Center for Cancer Research, National Cancer Institute, Bethesda, MD 20892. ^[5] Experimental Transplantation and Immunology Branch, Center for Cancer Research, National Cancer Institute, Bethesda, MD 20892; luca.gattinoni@ukr.de wjl@helix.nih.gov.;Regensburg Center for Interventional Immunology, University of Regensburg and University Hospital Regensburg, 93053 Regensburg, Germany. ^[6] Laboratory of Molecular Immunology and the Immunology Center, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20892; luca.gattinoni@ukr.de wjl@helix.nih.gov. ^[7]

关键词 IL-2 IL-21 LDH adoptive immunotherapy immunometabolism