Metabolomics analyses in non-diabetic middle-aged individuals reveal metabolites impacting early glucose disturbances and insulin sensitivity.

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第一作者： Maxime M,Bos

第一单位： Section of Gerontology and Geriatrics, Department of Internal Medicine, Leiden University Medical Center, PO Box 9600, 2300 RC, Leiden, The Netherlands. m.m.bos@lumc.nl.;AcureOmics AB, Umeå, Sweden. m.m.bos@lumc.nl.

作者： Maxime M,Bos ^[1] ; Raymond,Noordam ^[2] ; Kate,Bennett ^[3] ; Marian,Beekman ^[4] ; Dennis O,Mook-Kanamori ^[5] ; Ko,Willems van Dijk ^[6] ; P Eline,Slagboom ^[4] ; Torbjörn,Lundstedt ^[3] ; Izabella,Surowiec ^[7] ; Diana,van Heemst ^[8]

作者单位： Section of Gerontology and Geriatrics, Department of Internal Medicine, Leiden University Medical Center, PO Box 9600, 2300 RC, Leiden, The Netherlands. m.m.bos@lumc.nl.;AcureOmics AB, Umeå, Sweden. m.m.bos@lumc.nl. ^[1] Section of Gerontology and Geriatrics, Department of Internal Medicine, Leiden University Medical Center, PO Box 9600, 2300 RC, Leiden, The Netherlands.;AcureOmics AB, Umeå, Sweden. ^[2] AcureOmics AB, Umeå, Sweden. ^[3] Section of Molecular Epidemiology, Department of Biomedical Data Sciences, Leiden University Medical Center, Leiden, The Netherlands. ^[4] Department of Clinical Epidemiology, Leiden University Medical Center, Leiden, The Netherlands.;Department of Public Health and Primary Care, Leiden University Medical Center, Leiden, The Netherlands. ^[5] Department of Human Genetics, Leiden University Medical Center, Leiden, The Netherlands.;Division of Endocrinology, Department of Internal Medicine, Leiden University Medical Center, Leiden, The Netherlands.;Leiden Laboratory for Experimental Vascular Medicine, Leiden University Medical Center, Leiden, The Netherlands. ^[6] AcureOmics AB, Umeå, Sweden.;Department of Chemistry, Umeå University, Umeå, Sweden. ^[7] Section of Gerontology and Geriatrics, Department of Internal Medicine, Leiden University Medical Center, PO Box 9600, 2300 RC, Leiden, The Netherlands. ^[8]

关键词 Glucose metabolism Insulin sensitivity Metabolomics Type 2 diabetes mellitus