Prefrontal cortex infusion of beta-hydroxybutyrate, an endogenous NLRP3 inflammasome inhibitor, produces antidepressant-like effects in a rodent model of depression.

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作者： Naofumi,Kajitani ^[1] ; Masaaki,Iwata ^[1] ; Akihiko,Miura ^[1] ; Kyohei,Tsunetomi ^[1] ; Takehiko,Yamanashi ^[1] ; Ryoichi,Matsuo ^[1] ; Tsuyoshi,Nishiguchi ^[1] ; Saki,Fukuda ^[1] ; Mayu,Nagata ^[1] ; Midori,Shibushita ^[1] ; Takahira,Yamauchi ^[2] ; Shenghong,Pu ^[1] ; Yukihiko,Shirayama ^[3] ; Ken,Watanabe ^[4] ; Koichi,Kaneko ^[1]

作者单位： Department of Neuropsychiatry, Faculty of Medicine, Tottori University, Yonago, Japan. ^[1] Department of Psychiatry, Nara Medical University School of Medicine, Kashihara, Japan. ^[2] Department of Psychiatry, Teikyo University Chiba Medical Center, Ichihara, Japan. ^[3] Watanabe Hospital, Tottori, Japan. ^[4]

关键词 NLRP3 beta-hydroxybutyrate depression inflammasome prefrontal cortex stress

主题词 3-羟基丁酸(3-Hydroxybutyric Acid);动物(Animals);抗抑郁药(Antidepressive Agents);皮质酮(Corticosterone);抑郁(Depression);疾病模型, 动物(Disease Models, Animal);输注泵(Infusion Pumps);男(雄)性(Male);微量注射(Microinjections);额叶前皮质(Prefrontal Cortex);大鼠(Rats);大鼠, Sprague-Dawley(Rats, Sprague-Dawley);啮齿目(Rodentia)

DOI 10.1002/npr2.12099

PMID 32125791

发布时间 2021-08-16

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Neuropsychopharmacology reports

2020年40卷2期

157-165页

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Prefrontal cortex infusion of beta-hydroxybutyrate, an endogenous NLRP3 inflammasome inhibitor, produces antidepressant-like effects in a rodent model of depression.

Neuropsychopharmacology reports

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Neuropsychopharmacology reports

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Prefrontal cortex infusion of beta-hydroxybutyrate, an endogenous NLRP3 inflammasome inhibitor, produces antidepressant-like effects in a rodent model of depression.

Neuropsychopharmacology reports

相似文献

Neuropsychopharmacology reports

相关期刊

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