Engineering the Fab fragment of the anti-IgE omalizumab to prevent Fab crystallization and permit IgE-Fc complex crystallization.

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第一作者： Alkistis N,Mitropoulou

第一单位： Randall Centre for Cell and Molecular Biophysics, King's College London, New Hunt's House, London SE1 1UL, UK.

作者： Alkistis N,Mitropoulou ^[1] ; Tom,Ceska ^[2] ; James T,Heads ^[2] ; Andrew J,Beavil ^[1] ; Alistair J,Henry ^[2] ; James M,McDonnell ^[1] ; Brian J,Sutton ^[1] ; Anna M,Davies ^[1]

作者单位： Randall Centre for Cell and Molecular Biophysics, King's College London, New Hunt's House, London SE1 1UL, UK. ^[1] UCB Celltech, 208 Bath Road, Slough SL1 3WE, UK. ^[2]

关键词 Fab X-ray crystallography allergy antibody immunoglobulin E omalizumab protein engineering

主题词抗体, 抗独特型(Antibodies, Anti-Idiotypic);结晶(Crystallization);结晶学, X线(Crystallography, X-Ray);人类(Humans);免疫球蛋白E(Immunoglobulin E);免疫球蛋白Fab片段(Immunoglobulin Fab Fragments);免疫球蛋白Fc片段(Immunoglobulin Fc Fragments);蛋白质结构, 二级(Protein Structure, Secondary);蛋白质结构, 三级(Protein Structure, Tertiary)

DOI 10.1107/S2053230X20001466

PMID 32133997

发布时间 2023-11-13

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Acta crystallographica. Section F, Structural biology communications

2020年76卷Pt 3期

116-129页

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Engineering the Fab fragment of the anti-IgE omalizumab to prevent Fab crystallization and permit IgE-Fc complex crystallization.

Acta crystallographica. Section F, Structural biology communications

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Acta crystallographica. Section F, Structural biology communications

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Engineering the Fab fragment of the anti-IgE omalizumab to prevent Fab crystallization and permit IgE-Fc complex crystallization.

Acta crystallographica. Section F, Structural biology communications

相似文献

Acta crystallographica. Section F, Structural biology communications

相关期刊

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