Pathogen to commensal? Longitudinal within-host population dynamics, evolution, and adaptation during a chronic >16-year Burkholderia pseudomallei infection.

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作者： Talima,Pearson ^[1] ; Jason W,Sahl ^[1] ; Crystal M,Hepp ^[2] ; Karthik,Handady ^[1] ; Heidie,Hornstra ^[1] ; Adam J,Vazquez ^[1] ; Erik,Settles ^[1] ; Mark,Mayo ^[3] ; Mirjam,Kaestli ^[3] ; Charles H D,Williamson ^[1] ; Erin P,Price ^[1] ; Derek S,Sarovich ^[1] ; James M,Cook ^[1] ; Spenser R,Wolken ^[1] ; Richard A,Bowen ^[4] ; Apichai,Tuanyok ^[1] ; Jeffrey T,Foster ^[1] ; Kevin P,Drees ^[1] ; Timothy J,Kidd ^[5] ; Scott C,Bell ^[6] ; Bart J,Currie ^[7] ; Paul,Keim ^[1]

作者单位： Pathogen & Microbiome Institute, Northern Arizona University, Flagstaff, Arizona, United States of America. ^[1] Pathogen & Microbiome Institute, Northern Arizona University, Flagstaff, Arizona, United States of America.;School of Informatics, Computing, and Cyber Systems, Northern Arizona University, Flagstaff, Arizona, United States of America. ^[2] Global and Tropical Health Division, Menzies School of Health Research, Darwin, Northern Territory, Australia. ^[3] Department of Biomedical Sciences, Colorado State University, Colorado, United States of America. ^[4] School of Chemistry and Molecular Biosciences, University of Queensland, Brisbane, Queensland, Australia. ^[5] Department of Thoracic Medicine, The Prince Charles Hospital, Chermside, and QIMR Berghofer Medical Research Institute, Queensland, Australia. ^[6] Global and Tropical Health Division, Menzies School of Health Research, Darwin, Northern Territory, Australia.;Infectious Diseases Department and Northern Territory Medical Program, Royal Darwin Hospital, Darwin, Northern Territory, Australia. ^[7]