Inferring Causal Gene Regulatory Networks from Coupled Single-Cell Expression Dynamics Using Scribe.

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作者： Xiaojie,Qiu ^[1] ; Arman,Rahimzamani ^[2] ; Li,Wang ^[3] ; Bingcheng,Ren ^[4] ; Qi,Mao ^[5] ; Timothy,Durham ^[6] ; José L,McFaline-Figueroa ^[6] ; Lauren,Saunders ^[1] ; Cole,Trapnell ^[7] ; Sreeram,Kannan ^[8]

作者单位： Molecular & Cellular Biology Program, University of Washington, Seattle, WA, USA; Department of Genome Sciences, University of Washington, Seattle, WA, USA. ^[1] Department of Electrical Engineering, University of Washington, Seattle, WA, USA. ^[2] Department of Mathematics, University of Texas at Arlington, Arlington, TX, USA. ^[3] College of Information Science and Engineering, Hunan Normal University, Changsha, China. ^[4] HERE company, Chicago, IL 60606, USA. ^[5] Department of Genome Sciences, University of Washington, Seattle, WA, USA. ^[6] Molecular & Cellular Biology Program, University of Washington, Seattle, WA, USA; Department of Genome Sciences, University of Washington, Seattle, WA, USA; Brotman-Baty Institute for Precision Medicine, Seattle, WA, USA. Electronic address: coletrap@uw.edu. ^[7] Department of Electrical Engineering, University of Washington, Seattle, WA, USA. Electronic address: ksreeram@uw.edu. ^[8]

关键词 RNA velocity Scribe causal network inference coupled dynamics gene regulatory network inference pseudotime real time single-cell RNA-seq single-cell trajectories slam-seq

主题词算法(Algorithms);动物(Animals);细胞分化(Cell Differentiation);计算生物学(Computational Biology);数据库, 遗传学(Databases, Genetic);基因表达谱(Gene Expression Profiling);基因表达调控(Gene Expression Regulation);基因调控网络(Gene Regulatory Networks);人类(Humans);RNA(RNA);单细胞分析(Single-Cell Analysis);软件(Software)

DOI 10.1016/j.cels.2020.02.003

PMID 32135093

发布时间 2024-03-28

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Cell systems

2020年10卷3期

265-274.e11页

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Inferring Causal Gene Regulatory Networks from Coupled Single-Cell Expression Dynamics Using Scribe.

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Inferring Causal Gene Regulatory Networks from Coupled Single-Cell Expression Dynamics Using Scribe.

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