Loss of iRhom2 accelerates fat gain and insulin resistance in diet-induced obesity despite reduced adipose tissue inflammation.

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作者： Joseph,Skurski ^[1] ; Christie M,Penniman ^[2] ; Ramasatyaveni,Geesala ^[3] ; Garima,Dixit ^[3] ; Priyanjali,Pulipati ^[3] ; Gourav,Bhardwaj ^[2] ; David K,Meyerholz ^[4] ; Priya D,Issuree ^[3] ; Brian T,O'Neill ^[5] ; Thorsten,Maretzky ^[6]

作者单位： Inflammation Program, Roy J. and Lucille A. Carver College of Medicine University of Iowa, Iowa City, IA, USA; Department of Internal Medicine, Roy J. and Lucille A. Carver College of Medicine University of Iowa, Iowa City, IA, USA; Immunology Graduate Program, Iowa City, IA, USA. ^[1] Department of Internal Medicine, Roy J. and Lucille A. Carver College of Medicine University of Iowa, Iowa City, IA, USA; Division of Endocrinology and Metabolism, Fraternal Order of Eagles Diabetes Research Center, Roy J. and Lucille A. Carver College of Medicine University of Iowa, Iowa City, IA, USA. ^[2] Inflammation Program, Roy J. and Lucille A. Carver College of Medicine University of Iowa, Iowa City, IA, USA; Department of Internal Medicine, Roy J. and Lucille A. Carver College of Medicine University of Iowa, Iowa City, IA, USA. ^[3] Department of Pathology, Roy J. and Lucille A. Carver College of Medicine, Iowa City, IA, USA. ^[4] Department of Internal Medicine, Roy J. and Lucille A. Carver College of Medicine University of Iowa, Iowa City, IA, USA; Division of Endocrinology and Metabolism, Fraternal Order of Eagles Diabetes Research Center, Roy J. and Lucille A. Carver College of Medicine University of Iowa, Iowa City, IA, USA. Electronic address: brian-oneill@uiowa.edu. ^[5] Inflammation Program, Roy J. and Lucille A. Carver College of Medicine University of Iowa, Iowa City, IA, USA; Department of Internal Medicine, Roy J. and Lucille A. Carver College of Medicine University of Iowa, Iowa City, IA, USA; Immunology Graduate Program, Iowa City, IA, USA; Holden Comprehensive Cancer Center, University of Iowa, Iowa City, IA, USA. Electronic address: thorsten-maretzky@uiowa.edu. ^[6]

关键词 A disintegrin and metalloproteinase 17 (ADAM17)Inactive rhomboid 2 (iRhom2)Insulin resistance Rhomboid 5 homolog 2 (RHBDF2)Tumor necrosis factor (TNF)