Synthesis and Bioactivity Assessment of Novel Spiro Pyrazole-Oxindole Congeners Exhibiting Potent and Selective <i>in vitro</i> Anticancer Effects.

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作者： Heba M,Abo-Salem ^[1] ; Amr,Nassrallah ^[2] ; Ahmed A F,Soliman ^[3] ; Manal S,Ebied ^[1] ; Mohamed E,Elawady ^[4] ; Sayeda A,Abdelhamid ^[4] ; Eslam R,El-Sawy ^[1] ; Yazeed A,Al-Sheikh ^[5] ; Mourad A M,Aboul-Soud ^[5]

作者单位： Chemistry of Natural Compounds Department, National Research Centre, Dokki, 12622 Giza, Egypt. ^[1] Biochemistry Department, Faculty of Agriculture, Cairo University, 12613 Giza, Egypt. ^[2] Drug Bioassay-Cell Culture Laboratory, Pharmacognosy Department, National Research Center, Dokki, 12622 Giza, Egypt. ^[3] Microbial Biotechnology Department, National Research Centre, Dokki, 12622 Giza, Egypt. ^[4] Chair of Medical and Molecular Genetics Research, Department of Clinical Laboratory Sciences, College of Applied Medical Sciences, King Saud University, P.O. Box 10219, Riyadh 11433, Saudi Arabia. ^[5]

关键词 antiproliferative agents apoptosis isatin spiro pyrazole-oxindoles

主题词抗肿瘤药(Antineoplastic Agents);细胞凋亡(Apoptosis);HCT116细胞(HCT116 Cells);Hep G2细胞(Hep G2 Cells);人类(Humans);吡唑类(Pyrazoles);构效关系(Structure-Activity Relationship)

DOI 10.3390/molecules25051124

PMID 32138244

发布时间 2020-12-14

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准确一般字义偏差语意偏离译文作用小提交