Ebselen as template for stabilization of A4V mutant dimer for motor neuron disease therapy.-论文-万方医学网

第一作者： Varunya,Chantadul

第一单位： Faculty of Health and Life Sciences, Molecular Biophysics Group, Institute of Integrative Biology, University of Liverpool, Liverpool, L69 7ZB, UK.;Faculty of Dentistry, Department of Anatomy, Mahidol University, Bangkok, 10400, Thailand.

作者： Varunya,Chantadul ^[1] ; Gareth S A,Wright ^[2] ; Kangsa,Amporndanai ^[2] ; Munazza,Shahid ^[3] ; Svetlana V,Antonyuk ^[2] ; Gina,Washbourn ^[4] ; Michael,Rogers ^[4] ; Natalie,Roberts ^[4] ; Matthew,Pye ^[4] ; Paul M,O'Neill ^[4] ; S Samar,Hasnain ^[5]

作者单位： Faculty of Health and Life Sciences, Molecular Biophysics Group, Institute of Integrative Biology, University of Liverpool, Liverpool, L69 7ZB, UK.;Faculty of Dentistry, Department of Anatomy, Mahidol University, Bangkok, 10400, Thailand. ^[1] Faculty of Health and Life Sciences, Molecular Biophysics Group, Institute of Integrative Biology, University of Liverpool, Liverpool, L69 7ZB, UK. ^[2] Department of Chemistry and Chemical Engineering, Lahore University of Management Sciences, Punjab, 54792, Pakistan. ^[3] Faculty of Science and Engineering, Department of Chemistry, University of Liverpool, Liverpool, L69 7ZD, UK. ^[4] Faculty of Health and Life Sciences, Molecular Biophysics Group, Institute of Integrative Biology, University of Liverpool, Liverpool, L69 7ZB, UK. S.S.Hasnain@liverpool.ac.uk. ^[5]

医学主题词氨基酸取代(Amino Acid Substitution);氮杂茂类(Azoles);结晶学, X线(Crystallography, X-Ray);药物设计(Drug Design);药物发现(Drug Discovery);药物评价, 临床前(Drug Evaluation, Preclinical);人类(Humans);异吲哚类(Isoindoles);模型, 分子(Models, Molecular);分子伴侣(Molecular Chaperones);运动神经元病(Motor Neuron Disease);突变蛋白质类(Mutant Proteins);突变, 误义(Mutation, Missense);有机硒化合物(Organoselenium Compounds);蛋白质折叠(Protein Folding);蛋白质多聚化(Protein Multimerization);蛋白质稳定性(Protein Stability);蛋白质结构, 三级(Protein Structure, Tertiary);硫化合物(Sulfur Compounds);热力学(Thermodynamics)

DOI 10.1038/s42003-020-0826-3

PMID 32139772

发布时间 2025-05-30

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Ebselen as template for stabilization of A4V mutant dimer for motor neuron disease therapy.

Communications biology

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Ebselen as template for stabilization of A4V mutant dimer for motor neuron disease therapy.

Communications biology

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Communications biology

相关期刊

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