Interplay between whole-genome doubling and the accumulation of deleterious alterations in cancer evolution.

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作者： Saioa,López ^[1] ; Emilia L,Lim ^[2] ; Stuart,Horswell ^[2] ; Kerstin,Haase ^[3] ; Ariana,Huebner ^[4] ; Michelle,Dietzen ^[5] ; Thanos P,Mourikis ^[1] ; Thomas B K,Watkins ^[2] ; Andrew,Rowan ^[3] ; Sally M,Dewhurst ^[1] ; Nicolai J,Birkbak ^[2] ; Gareth A,Wilson ^[3] ; Peter,Van Loo ^[1] ; Mariam,Jamal-Hanjani ^[2] ; TRACERx Consortium ^[3] ; Charles,Swanton ^[3] ; Nicholas,McGranahan ^[6]

作者单位： Cancer Genome Evolution Research Group, University College London Cancer Institute, London, UK. ^[1] Cancer Research UK Lung Cancer Centre of Excellence, University College London Cancer Institute, London, UK. ^[2] Cancer Evolution and Genome Instability Laboratory, Francis Crick Institute and University College London Cancer Institute, London, UK. ^[3] Bioinformatics and Biostatistics Group, Francis Crick Institute, London, UK. ^[4] Cancer Genomics Laboratory, Francis Crick Institute, London, UK. ^[5] Laboratory for Cell Biology and Genetics, The Rockefeller University, New York, NY, USA. ^[6] Department of Molecular Medicine, Aarhus University, Aarhus, Denmark. ^[7] Department of Human Genetics, University of Leuven, Leuven, Belgium. ^[8] Department of Medical Oncology, University College London Hospitals NHS Foundation Trust, London, UK. ^[9] Cancer Research UK Lung Cancer Centre of Excellence, University College London Cancer Institute, London, UK. charles.swanton@crick.ac.uk. ^[10] Cancer Evolution and Genome Instability Laboratory, Francis Crick Institute and University College London Cancer Institute, London, UK. charles.swanton@crick.ac.uk. ^[11] Cancer Genome Evolution Research Group, University College London Cancer Institute, London, UK. nicholas.mcgranahan.10@ucl.ac.uk. ^[12] Cancer Research UK Lung Cancer Centre of Excellence, University College London Cancer Institute, London, UK. nicholas.mcgranahan.10@ucl.ac.uk. ^[13]