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Brain region-specific amyloid plaque-associated myelin lipid loss, APOE deposition and disruption of the myelin sheath in familial Alzheimer's disease mice.

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第一作者： Ibrahim,Kaya

第一单位： Department of Psychiatry and Neurochemistry, Sahlgrenska Academy at the University of Gothenburg, Mölndal, Sweden.;Department of Chemistry and Molecular Biology, University of Gothenburg, Gothenburg, Sweden.

作者： Ibrahim,Kaya ^[1] ; Eva,Jennische ^[2] ; Stefan,Lange ^[2] ; Ahmet,Tarik Baykal ^[3] ; Per,Malmberg ^[4] ; John S,Fletcher ^[5]

作者单位： Department of Psychiatry and Neurochemistry, Sahlgrenska Academy at the University of Gothenburg, Mölndal, Sweden.;Department of Chemistry and Molecular Biology, University of Gothenburg, Gothenburg, Sweden. ^[1] Institute of Biomedicine, University of Gothenburg, Gothenburg, Sweden. ^[2] Department of Medical Biochemistry, Faculty of Medicine, Acibadem Mehmet Ali Aydinlar University, Istanbul, Turkey. ^[3] Department of Chemistry and Chemical Engineering, Chalmers University of Technology, Gothenburg, Sweden. ^[4] Department of Chemistry and Molecular Biology, University of Gothenburg, Gothenburg, Sweden. ^[5]

关键词 Alzheimer's disease MALDI Imaging Mass Spectrometry amyloid plaques apolipoprotein E (APOE)myelin lipids sulfatides