MutT homologue 1 (MTH1) removes N6-methyl-dATP from the dNTP pool.

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第一作者： Emma Rose,Scaletti

第一单位： Department of Biochemistry and Biophysics, Stockholm University S-106 91, Stockholm, Sweden.

作者： Emma Rose,Scaletti ^[1] ; Karl S,Vallin ^[2] ; Lars,Bräutigam ^[3] ; Antonio,Sarno ^[3] ; Ulrika,Warpman Berglund ^[4] ; Thomas,Helleday ^[5] ; Pål,Stenmark ^[3] ; Ann-Sofie,Jemth ^[3]

作者单位： Department of Biochemistry and Biophysics, Stockholm University S-106 91, Stockholm, Sweden. ^[1] Department of Experimental Medical Science, Lund University, Lund 221 00, Sweden. ^[2] Science for Life Laboratory, Department of Oncology-Pathology, Karolinska Institutet, S-171 76 Stockholm, Sweden. ^[3] Department of Clinical and Molecular Medicine, Norwegian University of Science and Technology, 7491 Trondheim, Norway. ^[4] Department of Pathology, St. Olavs Hospital, 7006 Trondheim, Norway. ^[5] Weston Park Cancer Centre, Department of Oncology and Metabolism, University of Sheffield, Sheffield S10 2RX, United Kingdom. ^[6] Department of Biochemistry and Biophysics, Stockholm University S-106 91, Stockholm, Sweden stenmark@dbb.su.se. ^[7] Science for Life Laboratory, Department of Oncology-Pathology, Karolinska Institutet, S-171 76 Stockholm, Sweden annsofie.jemth@scilifelab.se. ^[8]

关键词 MutT homologue 1 (MTH1)N6-methyl-dATP Nudix hydrolase 1 (NUDT1)X-ray crystallography crystal structure enzyme catalysis enzyme kinetics epigenetics hydrolase methylation nucleoside/nucleotide metabolism nucleotide hydrolysis substrate specificity