Targeting RAGE prevents muscle wasting and prolongs survival in cancer cachexia.

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作者： Sara,Chiappalupi ^[1] ; Guglielmo,Sorci ^[2] ; Aleksandra,Vukasinovic ^[1] ; Laura,Salvadori ^[2] ; Roberta,Sagheddu ^[3] ; Dario,Coletti ^[1] ; Giorgia,Renga ^[2] ; Luigina,Romani ^[1] ; Rosario,Donato ^[2] ; Francesca,Riuzzi ^[1]

作者单位： Department of Experimental Medicine, University of Perugia, Perugia, Italy. ^[1] Interuniversity Institute of Myology, Perugia, Italy. ^[2] Centro Universitario di Ricerca sulla Genomica Funzionale, University of Perugia, Perugia, Italy. ^[3] Department of Anatomical, Histological, Forensic and Orthopedic Sciences, Sapienza University of Rome, Rome, Italy. ^[4] CNRS UMR 8256, INSERM ERL U1164, Biological Adaptation and Aging B2A, Sorbonne Université, Paris, France. ^[5]

关键词 Cancer cachexia Cytokines HMGB1 Inflammation Muscle atrophy Myogenin RAGE S100B

主题词动物(Animals);恶病质(Cachexia);人类(Humans);小鼠(Mice);肿瘤(Neoplasms)

DOI 10.1002/jcsm.12561

PMID 32159297

发布时间 2021-08-25

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