Design and rationale of a multi-center, pragmatic, open-label randomized trial of antimicrobial therapy - the study of clinical efficacy of antimicrobial therapy strategy using pragmatic design in Idiopathic Pulmonary Fibrosis (CleanUP-IPF) clinical trial.

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第一作者： Kevin J,Anstrom

第一单位： Duke Clinical Research Institute, Duke University, Durham, North Carolina, USA. kevin.anstrom@duke.edu.

作者： Kevin J,Anstrom ^[1] ; Imre,Noth ^[2] ; Kevin R,Flaherty ^[3] ; Rex H,Edwards ^[4] ; Joan,Albright ^[5] ; Amanda,Baucom ^[6] ; Maria,Brooks ^[6] ; Allan B,Clark ^[7] ; Emily S,Clausen ^[8] ; Michael T,Durheim ^[5] ; Dong-Yun,Kim ^[9] ; Jerry,Kirchner ^[10] ; Justin M,Oldham ^[5] ; Laurie D,Snyder ^[11] ; Andrew M,Wilson ^[5] ; Stephen R,Wisniewski ^[7] ; Eric,Yow ^[6] ; Fernando J,Martinez ^[5] ; CleanUP-IPF Study Team ^[12]

作者单位： Duke Clinical Research Institute, Duke University, Durham, North Carolina, USA. kevin.anstrom@duke.edu. ^[1] Division of Pulmonary Medicine, University of Virginia, Charlottesville, Virginia, USA. ^[2] Division of Pulmonary & Critical Care Medicine, University of Michigan Health System, Ann Arbor, MI, USA. ^[3] Pulmonary Fibrosis Foundation, Chicago, IL, USA. ^[4] Duke Clinical Research Institute, Duke University, Durham, North Carolina, USA. ^[5] Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA, USA. ^[6] Norwich Medical School, University of East Anglia, Norwich, UK. ^[7] Division of Pulmonary and Critical Care Medicine, University of Pennsylvania, Philadelphia, PA, USA. ^[8] Department of Respiratory Medicine, Oslo University Hospital - Rikshospitalet, Oslo, Norway. ^[9] National Heart, Lung and Blood Institute, National Institutes of Health, Bethesda, MD, USA. ^[10] UC Davis, Pulmonary, Critical Care, and Sleep Medicine, Davis, California, USA. ^[11] Division of Pulmonary Medicine, Weill-Cornell Medical Center, Cornell University, New York, NY, USA. ^[12]

关键词 Co-trimoxazole Doxycycline Idiopathic pulmonary fibrosis Pragmatic clinical trial

主题词抗感染药(Anti-Infective Agents);人类(Humans);特发性肺纤维化(Idiopathic Pulmonary Fibrosis);多中心研究(主题)(Multicenter Studies as Topic);随机对照试验(主题)(Randomized Controlled Trials as Topic);研究设计(Research Design);治疗结果(Treatment Outcome)

DOI 10.1186/s12931-020-1326-1

PMID 32164673

发布时间 2020-12-14

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