换一批
换一批PLCG2 protective variant p.P522R modulates tau pathology and disease progression in patients with mild cognitive impairment.
第一作者：
Luca,Kleineidam
第一单位：
Department of Neurodegenerative Diseases and Geriatric Psychiatry, University Hospital Bonn, Bonn, Germany.;Division of Neurogenetics and Molecular Psychiatry, Department of Psychiatry and Psychotherapy, Medical Faculty, University of Cologne, Cologne, Germany.;German Center for Neurodegenerative Diseases (DZNE), Bonn, Germany.
作者：
Luca,Kleineidam [1]
;
Vincent,Chouraki [2]
;
Tomasz,Próchnicki [3]
;
Sven J,van der Lee [4]
;
Laura,Madrid-Márquez [5]
;
Holger,Wagner-Thelen [6]
;
Ilker,Karaca [7]
;
Leonie,Weinhold [8]
;
Steffen,Wolfsgruber [9]
;
Anne,Boland [10]
;
Pamela V,Martino Adami [11]
;
Piotr,Lewczuk [12]
;
Julius,Popp [13]
;
Frederic,Brosseron [9]
;
Iris E,Jansen [14]
;
Marc,Hulsman [4]
;
Johannes,Kornhuber [15]
;
Oliver,Peters [16]
;
Claudine,Berr [17]
;
Reinhard,Heun [18]
;
Lutz,Frölich [19]
;
Christophe,Tzourio [20]
;
Jean-François,Dartigues [20]
;
Michael,Hüll [21]
;
Ana,Espinosa [22]
;
Isabel,Hernández [22]
;
Itziar,de Rojas [22]
;
Adelina,Orellana [23]
;
Sergi,Valero [22]
;
Najada,Stringa [24]
;
Natasja M,van Schoor [24]
;
Martijn,Huisman [24]
;
Philip,Scheltens [25]
;
Alzheimer’s Disease Neuroimaging Initiative (ADNI) [26]
;
Eckart,Rüther [10]
;
Jean-Francois,Deleuze [27]
;
Jens,Wiltfang [22]
;
Lluis,Tarraga [28]
;
Matthias,Schmid [29]
;
Martin,Scherer [30]
;
Steffi,Riedel-Heller [31]
;
Michael T,Heneka [32]
;
Philippe,Amouyel [33]
;
Frank,Jessen [22]
;
Merce,Boada [9]
;
Wolfgang,Maier [9]
;
Anja,Schneider [5]
;
Antonio,González-Pérez [25]
;
Wiesje M,van der Flier [9]
;
Michael,Wagner [32]
;
Jean-Charles,Lambert [4]
;
Henne,Holstege [5]
;
Mª Eugenia,Sáez [34]
;
Eicke,Latz [22]
;
Agustin,Ruiz [35]
;
Alfredo,Ramirez
作者单位：
Department of Neurodegenerative Diseases and Geriatric Psychiatry, University Hospital Bonn, Bonn, Germany.;Division of Neurogenetics and Molecular Psychiatry, Department of Psychiatry and Psychotherapy, Medical Faculty, University of Cologne, Cologne, Germany.;German Center for Neurodegenerative Diseases (DZNE), Bonn, Germany.
[1]
Univ. Lille, Inserm, CHU Lille, Institut Pasteur de Lille, U1167-RID-AGE-Facteurs de risque Et déterminants moléculaires des maladies liées au vieillissement, Lille, France.;Epidemiology and Public Health Department, Centre Hospitalier Universitaire de Lille, Lille, France.
[2]
Institute of Innate Immunity, University Hospitals Bonn, Bonn, Germany.
[3]
Department of Neurology, Alzheimer Center Amsterdam, Amsterdam Neuroscience, Amsterdam UMC, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands.;Department of Clinical Genetics, Amsterdam Neuroscience, Amsterdam UMC, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands.
[4]
Andalusian Bioinformatics Research Centre (CAEBi), Seville, Spain.
[5]
Department of Neurodegenerative Diseases and Geriatric Psychiatry, University Hospital Bonn, Bonn, Germany.;Division of Neurogenetics and Molecular Psychiatry, Department of Psychiatry and Psychotherapy, Medical Faculty, University of Cologne, Cologne, Germany.
[6]
Department of Neurodegenerative Diseases and Geriatric Psychiatry, University Hospital Bonn, Bonn, Germany.
[7]
Institute of Medical Biometry, Informatics and Epidemiology, University Hospital of Bonn, Bonn, Germany.
[8]
Department of Neurodegenerative Diseases and Geriatric Psychiatry, University Hospital Bonn, Bonn, Germany.;German Center for Neurodegenerative Diseases (DZNE), Bonn, Germany.
[9]
Centre National de Recherche en Génomique Humaine (CNRGH), Institut de Biologie François Jacob, CEA, Université Paris-Saclay, Évry, France.
[10]
Division of Neurogenetics and Molecular Psychiatry, Department of Psychiatry and Psychotherapy, Medical Faculty, University of Cologne, Cologne, Germany.
[11]
Department of Psychiatry and Psychotherapy, Universitätsklinikum Erlangen, and Friedrich-Alexander Universität Erlangen-Nürnberg, Erlangen, Germany.;Department of Neurodegeneration Diagnostics, Medical University of Białystok, Białystok, Poland.;Department of Biochemical Diagnostics, University Hospital of Białystok, Białystok, Poland.
[12]
Department of Psychiatry, Lausanne University Hospital, Prilly, Switzerland.;Department of Geriatric Psychiatry, University Hospital of Psychiatry Zurich, Zurich, Switzerland.
[13]
Department of Neurology, Alzheimer Center Amsterdam, Amsterdam Neuroscience, Amsterdam UMC, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands.;Department of Complex Trait Genetics, Center for Neurogenomics and Cognitive Research, Amsterdam Neuroscience, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands.
[14]
Department of Psychiatry and Psychotherapy, Universitätsklinikum Erlangen, and Friedrich-Alexander Universität Erlangen-Nürnberg, Erlangen, Germany.
[15]
Department of Psychiatry, Charité - Universitätsmedizin Berlin, Berlin, Germany.;DZNE, German Center for Neurodegenerative Diseases, Berlin, Germany.
[16]
INSERM, University Montpellier, Neuropsychiatry: Epidemiological and Clinical Research, Montpellier, France.
[17]
Department of Psychiatry and Psychotherapy, University Hospital Bonn, 53127, Bonn, Germany.
[18]
Department of Geriatric Psychiatry, Medical Faculty Mannheim, Central Institute of Mental Health, University of Heidelberg, Mannheim, Germany.
[19]
Inserm, Bordeaux Population Health Research Center, UMR1219, University of Bordeaux, Bordeaux, France.
[20]
Department of Psychiatry and Psychotherapy, Center for Psychiatry, Clinic for Geriatric Psychiatry and Psychotherapy Emmendingen, University of Freiburg, Freiburg, Germany.
[21]
Research Center and Memory Clinic, Fundació ACE, Institut Català de Neurociències Aplicades-Universitat Internacional de Catalunya-Barcelona, Barcelona, Spain.;Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas (CIBERNED), Instituto de Salud Carlos III, Madrid, Spain.
[22]
Research Center and Memory Clinic, Fundació ACE, Institut Català de Neurociències Aplicades-Universitat Internacional de Catalunya-Barcelona, Barcelona, Spain.
[23]
Department of Epidemiology and Biostatistics, Amsterdam Public Health Research Institute, Amsterdam UMC-Vrije Universiteit Amsterdam, Amsterdam, The Netherlands.
[24]
Department of Neurology, Alzheimer Center Amsterdam, Amsterdam Neuroscience, Amsterdam UMC, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands.
[25]
Department of Psychiatry and Psychotherapy, University Medical Center Göttingen, Göttingen, Germany.
[26]
Department of Psychiatry and Psychotherapy, University Medical Center Göttingen, Göttingen, Germany.;German Center for Neurodegenerative Diseases (DZNE), Göttingen, Germany.;iBiMED, Medical Sciences Department, University of Aveiro, Aveiro, Portugal.
[27]
German Center for Neurodegenerative Diseases (DZNE), Bonn, Germany.;Institute of Medical Biometry, Informatics and Epidemiology, University Hospital of Bonn, Bonn, Germany.
[28]
Department of Primary Medical Care, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
[29]
Institute of Social Medicine, Occupational Health and Public Health, University of Leipzig, Leipzig, Germany.
[30]
Department of Neurodegenerative Diseases and Geriatric Psychiatry, University Hospital Bonn, Bonn, Germany.;German Center for Neurodegenerative Diseases (DZNE), Bonn, Germany.;Division of Infectious Diseases and Immunology, Department of Medicine, University of Massachusetts Medical School, Worcester, MA, USA.
[31]
Univ. Lille, Inserm, CHU Lille, Institut Pasteur de Lille, U1167-RID-AGE-Facteurs de risque Et déterminants moléculaires des maladies liées au vieillissement, Lille, France.
[32]
German Center for Neurodegenerative Diseases (DZNE), Bonn, Germany.;Department of Psychiatry and Psychotherapy, Medical Faculty, University of Cologne, Cologne, Germany.
[33]
German Center for Neurodegenerative Diseases (DZNE), Bonn, Germany.;Institute of Innate Immunity, University Hospitals Bonn, Bonn, Germany.;Division of Infectious Diseases and Immunology, Department of Medicine, University of Massachusetts Medical School, Worcester, MA, USA.;Centre for Molecular Inflammation Research (CEMIR), Norwegian University of Science and Technology, Trondheim, Norway.
[34]
Department of Neurodegenerative Diseases and Geriatric Psychiatry, University Hospital Bonn, Bonn, Germany. alfredo.ramirez@uk-koeln.de.;Division of Neurogenetics and Molecular Psychiatry, Department of Psychiatry and Psychotherapy, Medical Faculty, University of Cologne, Cologne, Germany. alfredo.ramirez@uk-koeln.de.
[35]
主题词
老年人(Aged);老年人, 80以上(Aged, 80 and over);阿尔茨海默病(Alzheimer Disease);淀粉样β肽类(Amyloid beta-Peptides);认知(Cognition);疾病恶化(Disease Progression);女(雌)性(Female);人类(Humans);男(雄)性(Male);中年人(Middle Aged);磷脂酶Cγ(Phospholipase C gamma);tau蛋白质类(tau Proteins)
DOI
10.1007/s00401-020-02138-6
PMID
32166339
发布时间
2024-06-15
- 浏览23
Acta neuropathologica
Acta neuropathologica
1025-1044页
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