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Development and Structural Evaluation of N-Alkylated trans-2-Phenylcyclopropylamine-Based LSD1 Inhibitors.

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第一作者： Hideaki,Niwa

第一单位： RIKEN Systems and Structural Biology Center, Yokohama, 230-0045, Japan.;RIKEN Center for Life Science Technologies, Yokohama, 230-0045, Japan.;RIKEN Center for Biosystems Dynamics Research, Yokohama, 230-0045, Japan.

作者： Hideaki,Niwa ^[1] ; Shin,Sato ^[1] ; Noriko,Handa ^[2] ; Toru,Sengoku ^[3] ; Takashi,Umehara ^[1] ; Shigeyuki,Yokoyama ^[4]

作者单位： RIKEN Systems and Structural Biology Center, Yokohama, 230-0045, Japan.;RIKEN Center for Life Science Technologies, Yokohama, 230-0045, Japan.;RIKEN Center for Biosystems Dynamics Research, Yokohama, 230-0045, Japan. ^[1] RIKEN Systems and Structural Biology Center, Yokohama, 230-0045, Japan. ^[2] RIKEN Systems and Structural Biology Center, Yokohama, 230-0045, Japan.;RIKEN Structural Biology Laboratory, Yokohama, 230-0045, Japan. ^[3] RIKEN Systems and Structural Biology Center, Yokohama, 230-0045, Japan.;RIKEN Structural Biology Laboratory, Yokohama, 230-0045, Japan.;RIKEN Yokoyama Laboratory, Yokohama, 230-0045, Japan. ^[4]

关键词 X-ray crystallography chromatin epigenetics histone demethylase inhibitors nucleosomes protein structures

医学主题词烷化作用(Alkylation);酶抑制剂(Enzyme Inhibitors);组蛋白脱甲基酶类(Histone Demethylases);人类(Humans);模型, 分子(Models, Molecular);分子结构(Molecular Structure);反苯环丙铵(Tranylcypromine)

DOI 10.1002/cmdc.202000014

PMID 32166890

发布时间 2021-05-20

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